P29951

PR
Gene name
manA (AN0667)
Protein name
Mannose-6-phosphate isomerase
Names
Phosphohexomutase, Phosphomannose isomerase, PMI
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN0667.2
EC number
5.3.1.8: Interconverting aldoses and ketoses
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

81-267 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P29951

Entry ID Method Resolution Chain Position Source
AF-P29951-F1 Predicted AlphaFoldDB

No variants for P29951

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P29951

No associated diseases with P29951

5 regional properties for P29951

Type Name Position InterPro Accession
conserved_site Phosphomannose isomerase, type I, conserved site 126 - 134 IPR018050-1
conserved_site Phosphomannose isomerase, type I, conserved site 291 - 316 IPR018050-2
domain Phosphomannose isomerase type I, C-terminal domain 360 - 409 IPR046456
domain Phosphomannose isomerase type I, catalytic domain 5 - 151 IPR046457
domain Phosphomannose isomerase type I, helical insertion domain 167 - 272 IPR046458

Functions

Description
EC Number 5.3.1.8 Interconverting aldoses and ketoses
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
mannose-6-phosphate isomerase activity Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
GDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQVPLLRLQC GVNSYDWGRV GPESAAAKYA AATAPSDFTI EADKPYAELW MGTHPSLPSK
70 80 90 100 110 120
DVETQRTLLD MVQDNLALMS PEVSERYGGK LPFLFKVLSI RKALSIQAHP NKKLAEALHA
130 140 150 160 170 180
RDPRNYPDDN HKPEMTIAIT PFEGLCGFRP LAEIVHFLKA VAPLRYLIGV QTATDFENAV
190 200 210 220 230 240
RGFENTEDPE QTKKNKVALR TLFTSLMQSA SENIEQAARE LVAAAQSSPE TFASLVNAPD
250 260 270 280 290 300
TNPTNAAELA SIIIRLNEQF PNDIGLFVFF FLNFVRLEPG EAMFLKADDI HAYISGDIIE
310 320 330 340 350 360
CMASSDNVVR AGFTPKFKDV DTLTEMLTYS YAPIDEQKLQ PTDYPYTVLN AAAYSSASDS
370 380 390 400 410 420
LLYDPPIEEF SVVKTSLRRT GAKATFDPLT GPSILICTGG TGKISVGHKT EEVKEGYVFF
430 440 450 460
VGANAECIIE NTGTGSDEEN VFTTFKAFCD LTGKEDMANG H