P29749

PR
Gene name
tthHB8IM
Protein name
Type II methyltransferase M.TthHB8I
Names
M.TthHB8I, Adenine-specific methyltransferase TthHB8I, Modification methylase TthHB8I
Species
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
KEGG Pathway
ttj:TTHA1583
EC number
2.1.1.72: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

379-428 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P29749

Entry ID Method Resolution Chain Position Source
AF-P29749-F1 Predicted AlphaFoldDB

No variants for P29749

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P29749

No associated diseases with P29749

3 regional properties for P29749

Type Name Position InterPro Accession
conserved_site DNA methylase, N-6 adenine-specific, conserved site 100 - 106 IPR002052
domain Type II restriction enzyme and methyltransferase RM.Eco57I-like 97 - 206 IPR011639
domain TaqI-like C-terminal specificity domain 289 - 402 IPR025931

Functions

Description
EC Number 2.1.1.72 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
site-specific DNA-methyltransferase (adenine-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

1 GO annotations of biological process

Name Definition
DNA restriction-modification system A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLFPPSLPPT ASGRSLGRVE TPPGLVRFMV GLAEAPKGGR VLEPACADGP FLRAFREAHG
70 80 90 100 110 120
TGYRFVGVEI DPHALDLPPW AEGVVADFLL WEPGEAFDLI LGNPPYGIVG EASKYPIHVL
130 140 150 160 170 180
REVKGLYKKT LSTWKGKYNL YGAFIEKSVR LLREGGTLVF VVPATWLVLD DFSLLRSFLA
190 200 210 220 230 240
REGRTEVYYL GEVFPGRKVS AVVLRFRKGG KGLALWDTRR DGETFTPLLW SEKPEWKGEI
250 260 270 280 290 300
IRFETGWTRE MEASGPPLGS LFHIRFAARS PEFKKHPAVQ KEPEPGLVPV LTGRNLKPGW
310 320 330 340 350 360
IDYESNHSGL WMPKERAKEL RDFYATPHLV VAHTKGTKVV AAWDEKAYPW REEFHLLPKE
370 380 390 400 410 420
GVELDPLFLV EWLNSDKIQE YVKTLYRDFV PHLTLRMLER IPALLPRKGN TERRKHGPYT
SPESAGSF