P28894

PR
Gene name
fumC2
Protein name
Fumarate hydratase class II 2
Names
Fumarase C 2, Aerobic fumarase 2, Iron-independent fumarase 2
Species
Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
KEGG Pathway
bja:blr6519
EC number
4.2.1.2: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P28894

Entry ID Method Resolution Chain Position Source
AF-P28894-F1 Predicted AlphaFoldDB

No variants for P28894

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P28894

No associated diseases with P28894

3 regional properties for P28894

Type Name Position InterPro Accession
domain Fumarase C, C-terminal 418 - 471 IPR018951
conserved_site Fumarate lyase, conserved site 327 - 336 IPR020557
domain Fumarate lyase, N-terminal 22 - 352 IPR022761

Functions

Description
EC Number 4.2.1.2 Hydro-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle.

1 GO annotations of molecular function

Name Definition
fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H(2)O.

3 GO annotations of biological process

Name Definition
fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKSARTKTA RPATRTETDS FGPIEVPSDR YWGAQTERSR QNFRIGTDRM PISLVHALGI
70 80 90 100 110 120
VKLAAAQSNR ELGLLDQRRA SAIIRAAREV IDGSLDDHFP LVVWQTGSGT QTNMNLNEVI
130 140 150 160 170 180
ANRANELLGG ELGAKKPVHP NDHVNMSQSS NDSFPTAMHI AAASRITADL VPALGELLRA
190 200 210 220 230 240
LRKKEKEFAK IVKIGRTHTQ DATPLTLGQE FSGYAAQVES GIARLKVAVK ELYPLAQGGT
250 260 270 280 290 300
AVGTGLNAKP RFARLFAKHV AGITKLPFTS AANKFEALAS NDAYVLAHGA ISSVATGLFK
310 320 330 340 350 360
IANDIRLLGS GPRSGLGELI LPENEPGSSI MPGKVNPTQC EAMTMVCCQV FGNHTAITVA
370 380 390 400 410 420
GSQGHFELNV YKPVLAYNML HSIRLMADAA RSFTEHCVSG IRADEKRISE LMQRSLMLVT
430 440 450 460 470
ALAPKIGYDN AAKVAKTAHA NGTTLKEEAL RLGFVTADEF DRLVQPEKMT KPG