P28824

PR
Gene name
nrp1
Protein name
Neuropilin-1
Names
A5 antigen, A5 protein
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

410-484 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P28824

Entry ID Method Resolution Chain Position Source
AF-P28824-F1 Predicted AlphaFoldDB

No variants for P28824

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P28824

No associated diseases with P28824

6 regional properties for P28824

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 274 - 424 IPR000421-1
domain Coagulation factor 5/8 C-terminal domain 430 - 584 IPR000421-2
domain CUB domain 27 - 141 IPR000859-1
domain CUB domain 147 - 265 IPR000859-2
domain MAM domain 646 - 812 IPR000998
domain Neuropilin, C-terminal 848 - 927 IPR022579

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion membrane ; Single-pass type I membrane protein
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
growth factor binding Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
metal ion binding Binding to a metal ion.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
vascular endothelial growth factor receptor activity Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

6 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
endothelial cell chemotaxis The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
regulation of plasma membrane bounded cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.
vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLRLLSCCC WLLCSLRSSW ASRNDKCGDT IKITSPSYLT SAGYPHSYPP SQRCEWLIQA
70 80 90 100 110 120
PEHYQRIMIN FNPHFDLEDR ECKYDYVEVI DGDNANGQLL GKYCGKIAPS PLVSTGPSIF
130 140 150 160 170 180
IRFVSDYETP GAGFSIRYEV FKTGPECSRN FTSSNGVIKS PKYPEKYPNA LECTYIIFAP
190 200 210 220 230 240
KMQEIVLEFE SFELEADSNA PGGQTCRYDW LGIWDGFPGV GPHIGRYCGQ NTPGRVRSFT
250 260 270 280 290 300
GILSMIFHTD SAIAKEGFFA NFSVVQSNTD EDFQCKEALG MESGEIHFDQ ISVSSQYSMN
310 320 330 340 350 360
WSAERSRLNY VENGWTPGED TVKEWIQVDL ENLRFVSGIG TQGAISKETK KKYFVKSYKV
370 380 390 400 410 420
DISSNGEDWI TLKDGNKHLV FTGNTDATDV VYRPFSKPVI TRFVRLRPVT WENGISLRFE
430 440 450 460 470 480
LYGCKITDYP CSRMLGMVSG LISDSQITAS SQVDRNWVPE LARLVTSRSG WALPPSNTHP
490 500 510 520 530 540
YTKEWLQIDL AEEKIVRGVI IQGGKHKENK VFMRKFKIGY SNNGTEWEMI MDSSKNKPKT
550 560 570 580 590 600
FEGNTNYDTP ELRTFAHITT GFIRIIPERA SASGLALRLE LLGCEVETPT SIPTTPEVNG
610 620 630 640 650 660
GDECEGDLAN CHSGTDEGFK LTVGATGQST ETPTVEASPE EPDMTHSDLD CKFGWGSQKT
670 680 690 700 710 720
VCNWQHDISS DLKWAVLNSK TGPVQDHTGD GNFIYSEADE RHEGRAARLM SPVVSSSRSA
730 740 750 760 770 780
HCLTFWYHMD GSHVGTLSIK LKYEMEEDFD QTLWTVSGNQ GDQWKEARVV LHKTMKQYQV
790 800 810 820 830 840
IVEGTVGKGS AGGIAVDDII IANHISPSQC RAPEIDDSAN KIGEEDSEID KTGSTPNYAL
850 860 870 880 890 900
NEFNESISKK PGNVLKTLDP ILITIIAMSA LGVLLGAICG VVLYCACWHN GMSERNLSAL
910 920
ENYNFELVDG VKLKKDKLNT QNSYSEAS