P28774

PR
Gene name
Protein name
Sodium/potassium-transporting ATPase subunit alpha-B
Names
Na(+)/K(+) ATPase alpha-B subunit, Sodium pump subunit alpha-B
Species
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
KEGG Pathway
EC number
7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P28774

Entry ID Method Resolution Chain Position Source
AF-P28774-F1 Predicted AlphaFoldDB

No variants for P28774

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P28774

No associated diseases with P28774

4 regional properties for P28774

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 22 - 96 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 780 - 989 IPR006068
ptm P-type ATPase, phosphorylation site 357 - 363 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 336 - 748 IPR044492

Functions

Description
EC Number 7.2.2.13 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding Binding to a metal ion.
P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKGKQKKGK DLNELKKELD IDFHKIPIEE CYQRLGSNPE TGLTNAQARS NIERDGPNCL
70 80 90 100 110 120
TPPKTTPEWI KFCKNLFGGF ALLLWTGAIL CFLAYGIEAS SGNEDMLKDN LYLGIVLATV
130 140 150 160 170 180
VIVTGIFSYY QENKSSRIMD SFKNLVPQYA LALREGQRVT LKAEELTMGD IVEVKFGDRV
190 200 210 220 230 240
PADLRVLEAR SFKVDNSSLT GESEPQARSP EFTNDNPLET KNLAFFSTNA VEGTMRGIVI
250 260 270 280 290 300
GIGDNTVMGR IAGLASGLDT GETPIAKEIA HFIHIITGVA VFLGVTFFII AFVLGYHWLD
310 320 330 340 350 360
AVVFLIGIIV ANVPEGLLAT VTVCLTLTAK RMASKNCLVK NLEAVETLGS TSTICSDKTG
370 380 390 400 410 420
TLTQNRMTVA HMWFDGTITE ADTTEDQSGA QFDKSSAGWK ALVKIAALCS RAEFKPNQST
430 440 450 460 470 480
TPILKREVTG DASEAAILKC VELTTGETEA IRKRNKKICE IPFNSANKFQ VSIHENEDKS
490 500 510 520 530 540
DGRYLLVMKG APERILERCS TIFMNGKEID MTEELKEAFN NAYMELGGLG ERVLGFCDYL
550 560 570 580 590 600
LPLDKYPHGF AFNADDANFP LTGLRFAGLM SMIDPPRAAV PDAVAKCRSA GIKVIMVTGD
610 620 630 640 650 660
HPITAKAIAK SVGIISEGNE TVEDIAARLN IPVSEVNPRD AKAAVVHGGE LRDITPDALD
670 680 690 700 710 720
EILRHHPEIV FARTSPQQKL IIVEGCQRQG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS
730 740 750 760 770 780
DVSKQAADMI LLDDNFASIV TGVEEGRLIF DNLKKSIVYT LTSNIPEISP FLLFILFDIP
790 800 810 820 830 840
LPLGTVTILC IDLGTDMVPA ISLAYEEAES DIMKRRPRNP VTDKLVNERL ISLAYGQIGM
850 860 870 880 890 900
IQASAGFFVY FVIMAECGFL PWDLFGLRKH WDSRAVNDLT DSYGQEWTYD ARKQLESSCH
910 920 930 940 950 960
TAYFVSIVIV QWADLIISKT RRNSVFQQGM RNNILNFALV FETCLAAFLS YTPGMDKGLR
970 980 990 1000
MYPLKINWWF PALPFSFLIF VYDEARKFIL RRNPGGWVEQ ETYY