Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

225-247 (Activation loop from InterPro)

Target domain

81-339 (Protein kinase domain)

Relief mechanism

Assay

Autoinhibited structure

Activated structure

1 structures for P28582

Entry ID Method Resolution Chain Position Source
AF-P28582-F1 Predicted AlphaFoldDB

No variants for P28582

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P28582

No associated diseases with P28582

7 regional properties for P28582

Type Name Position InterPro Accession
domain Protein kinase domain 81 - 339 IPR000719
domain EF-hand domain 382 - 453 IPR002048-1
domain EF-hand domain 456 - 522 IPR002048-2
active_site Serine/threonine-protein kinase, active site 201 - 213 IPR008271
binding_site Protein kinase, ATP binding site 87 - 114 IPR017441
binding_site EF-Hand 1, calcium-binding site 395 - 407 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 500 - 512 IPR018247-2

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding Binding to a calcium ion (Ca2+).
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGGCFSKKEY QADGNGYRSA PTAYHTVTDQ SYEKSSQRSQ PQAQPQPQVQ QTGPSLKPRQ
70 80 90 100 110 120
VHRPESNTIL GKPFEDIRGK YTLGKELGRG QFGCVYQCTE NSSGQLYACK SILKRKLVSK
130 140 150 160 170 180
NDKEDIKREI QILQHLSGQP NIVEFKGVFE DRQSVHLVME LCAGGELFDR IIAQGHYSER
190 200 210 220 230 240
AAATICRQIV NVVHVCHFMG VMHRDLKPEN FLLSSKDKDA MLKATDFGLS VFIEEGKVYR
250 260 270 280 290 300
NIVGSAYYVA PEVLRRSYGK EIDIWSAGVI LYILLSGVPP FWAENEKGIF DAILEGVIDF
310 320 330 340 350 360
ESEPWPSVSN SAKDLVRKML TQDPRRRITS AQVLDHPWMR EGGEASDKPI DSAVLSRMKQ
370 380 390 400 410 420
FRAMNKLKQL ALKVIAESLS EEEIKGLKSM FANMDTDKSG TITYEELKSG LARLGSKLSE
430 440 450 460 470 480
VEVQQLMDAA DVDGNGTIDY LEFITATMHR HKLESYEHQA FQYFDKDNSG FITKDELESA
490 500 510 520 530
MKEYGMGDEA TIKDIISEVD SDNDGRINYD EFCAMMRRAR NRRKLFSVSL TS