P28522

PR
Gene name
Protein name
Ribosome-inactivating protein
Names
rRNA N-glycosidase
Species
Zea mays (Maize)
KEGG Pathway
EC number
3.2.2.22: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P28522

Entry ID Method Resolution Chain Position Source
2K6H NMR - PDB
2PQI X-ray 250 A PDB
2PQJ X-ray 280 A PDB
AF-P28522-F1 Predicted AlphaFoldDB

No variants for P28522

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P28522

No associated diseases with P28522

1 regional properties for P28522

Type Name Position InterPro Accession
conserved_site Ribosome-inactivating protein conserved site 202 - 218 IPR017988

Functions

Description
EC Number 3.2.2.22 Hydrolyzing N-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
rRNA N-glycosylase activity Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species.
toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.

2 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P25891 CRIP3 Ribosome-inactivating protein 3 Zea mays (Maize) PR
P10593 O6 Albumin b-32 Zea mays (Maize) PR
P25892 CRIP9 Ribosome-inactivating protein 9 Zea mays (Maize) PR
10 20 30 40 50 60
MAEITLEPSD LMAQTNKRIV PKFTEIFPVE DANYPYSAFI ASVRKDVIKH CTDHKGIFQP
70 80 90 100 110 120
VLPPEKKVPE LWFYTELKTR TSSITLAIRM DNLYLVGFRT PGGVWWEFGK DGDTHLLGDN
130 140 150 160 170 180
PRWLGFGGRY QDLIGNKGLE TVTMGRAEMT RAVNDLAKKK KMATLEEEEV KMQMQMPEAA
190 200 210 220 230 240
DLAAAAAADP QADTKSKLVK LVVMVCEGLR FNTVSRTVDA GFNSQHGVTL TVTQGKQVQK
250 260 270 280 290 300
WDRISKAAFE WADHPTAVIP DMQKLGIKDK NEAARIVALV KNQTTAAAAT AASADNDDDE
A