P28366

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU35300
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

759-838 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for P28366

Entry ID Method Resolution Chain Position Source
1M6N X-ray 270 A A 1-802 PDB
1M74 X-ray 300 A A 1-802 PDB
1TF2 X-ray 290 A A 1-841 PDB
1TF5 X-ray 218 A A 1-841 PDB
2IBM X-ray 320 A A/B 1-780 PDB
3DL8 X-ray 750 A A/B 1-779 PDB
3IQM X-ray 340 A A 1-802 PDB
3IQY X-ray 330 A A 1-841 PDB
3JV2 X-ray 250 A A/B 1-780 PDB
5EUL X-ray 370 A A 1-780 PDB
6ITC EM 345 A A 1-780 PDB
7XHA EM 335 A A 1-778 PDB
7XHB EM 333 A A 1-778 PDB
AF-P28366-F1 Predicted AlphaFoldDB

No variants for P28366

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P28366

No associated diseases with P28366

9 regional properties for P28366

Type Name Position InterPro Accession
domain Helicase, C-terminal 421 - 575 IPR001650
conserved_site SEC-C motif 821 - 839 IPR004027
domain SecA DEAD-like, N-terminal 5 - 382 IPR011115
domain SecA Wing/Scaffold 568 - 778 IPR011116
domain SecA, preprotein cross-linking domain 226 - 338 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 87 - 257 IPR014001
domain SecA motor DEAD 1 - 570 IPR014018
conserved_site SecA conserved site 480 - 495 IPR020937
domain SecA, C-terminal helicase domain 400 - 540 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Membrane raft
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell envelope Sec protein transport complex A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.

4 GO annotations of molecular function

Name Definition
ABC-type protein transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

4 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
protein transport by the Sec complex The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLGILNKMFD PTKRTLNRYE KIANDIDAIR GDYENLSDDA LKHKTIEFKE RLEKGATTDD
70 80 90 100 110 120
LLVEAFAVVR EASRRVTGMF PFKVQLMGGV ALHDGNIAEM KTGEGKTLTS TLPVYLNALT
130 140 150 160 170 180
GKGVHVVTVN EYLASRDAEQ MGKIFEFLGL TVGLNLNSMS KDEKREAYAA DITYSTNNEL
190 200 210 220 230 240
GFDYLRDNMV LYKEQMVQRP LHFAVIDEVD SILIDEARTP LIISGQAAKS TKLYVQANAF
250 260 270 280 290 300
VRTLKAEKDY TYDIKTKAVQ LTEEGMTKAE KAFGIDNLFD VKHVALNHHI NQALKAHVAM
310 320 330 340 350 360
QKDVDYVVED GQVVIVDSFT GRLMKGRRYS EGLHQAIEAK EGLEIQNESM TLATITFQNY
370 380 390 400 410 420
FRMYEKLAGM TGTAKTEEEE FRNIYNMQVV TIPTNRPVVR DDRPDLIYRT MEGKFKAVAE
430 440 450 460 470 480
DVAQRYMTGQ PVLVGTVAVE TSELISKLLK NKGIPHQVLN AKNHEREAQI IEEAGQKGAV
490 500 510 520 530 540
TIATNMAGRG TDIKLGEGVK ELGGLAVVGT ERHESRRIDN QLRGRSGRQG DPGITQFYLS
550 560 570 580 590 600
MEDELMRRFG AERTMAMLDR FGMDDSTPIQ SKMVSRAVES SQKRVEGNNF DSRKQLLQYD
610 620 630 640 650 660
DVLRQQREVI YKQRFEVIDS ENLREIVENM IKSSLERAIA AYTPREELPE EWKLDGLVDL
670 680 690 700 710 720
INTTYLDEGA LEKSDIFGKE PDEMLELIMD RIITKYNEKE EQFGKEQMRE FEKVIVLRAV
730 740 750 760 770 780
DSKWMDHIDA MDQLRQGIHL RAYAQTNPLR EYQMEGFAMF EHMIESIEDE VAKFVMKAEI
790 800 810 820 830 840
ENNLEREEVV QGQTTAHQPQ EGDDNKKAKK APVRKVVDIG RNAPCHCGSG KKYKNCCGRT
E