P28365

PR
Gene name
RPA2
Protein name
DNA-directed RNA polymerase I subunit RPA2
Names
RNA polymerase I subunit 2
Species
Euplotoides octocarinatus (Freshwater ciliate) (Euplotes octocarinatus)
KEGG Pathway
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

626-696 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P28365

Entry ID Method Resolution Chain Position Source
AF-P28365-F1 Predicted AlphaFoldDB

No variants for P28365

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P28365

No associated diseases with P28365

7 regional properties for P28365

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 672 - 1042 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 891 - 903 IPR007121
domain RNA polymerase Rpb2, domain 7 1044 - 1162 IPR007641
domain RNA polymerase Rpb2, domain 2 175 - 362 IPR007642
domain RNA polymerase, beta subunit, protrusion 19 - 400 IPR007644
domain RNA polymerase Rpb2, domain 3 451 - 511 IPR007645
domain DNA-directed RNA polymerase I subunit RPA2, domain 4 560 - 623 IPR009674

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
metal ion binding Binding to a metal ion.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTNAKFDRK EISKIYKNIA RHHIDSFDFA MSTCLNRACE HMLPFDYIVP EESASCGFKK
70 80 90 100 110 120
LTLWYDSFEL GQPSLGEIDY DSHILYPSEC RQRKMTYTIP LFATIFKKFD DEMVDNFKVK
130 140 150 160 170 180
LGDIPTMGRK KFCNLKGLTK KELAKRGEDM LEFGGYFIVN GNEKVIRMLI VPKRNFPIAF
190 200 210 220 230 240
KRSKFLERGK DFTDYGVQMR CVRDDFTAQT ITLTYLSDGS VSLRLIYQKQ EFLIPIILIL
250 260 270 280 290 300
KALKNCTDRQ IYERIVKGNF NQRQISDRVE AILAVGKDLN IYDSDQSKAL IGSRFRIVLA
310 320 330 340 350 360
GITSETSDID AGDLFLSKHI CIHTDSYEAK FDTLILMIDK LYASVANEVE LDNLDSVAMQ
370 380 390 400 410 420
DVLLGGHLYL QILSEKLFDC LHINLRARLN KELKRHNFDP MKFRDVLTNQ KINCGIGLIG
430 440 450 460 470 480
KRMENFLATG NLISRTNLDL MQTSGFCIIG DKLNNIRFLS HFRSIHRGQY FAEQKTTSVR
490 500 510 520 530 540
KLLPESWGFI CPVHTPDGAP CGLLNHISMS CVPIGSEEKQ IDIDKFRNIL GELGMNSISS
550 560 570 580 590 600
DLCLNYHTGY YPVIFDGIHL GYVEKDIGES FVEGLRYLKC TQSQPDYAIP RTLEIAFIPF
610 620 630 640 650 660
SGYSRNLQWP GIFLASTPAR FTRPVKNLHY NCIEWISPLE QMNLSIACTD EDITPETTHQ
670 680 690 700 710 720
ELDPINILSI VASVGVFAEY NQSPRNMYQC QMAKQTMGTP YHNHQFRTDN KIYRLLFPHR
730 740 750 760 770 780
PIVKTRTQVD FDIEEYPSGT NAVVAVISYT GYDLEDAMII NKSSYERGFG HGVVYKSYTH
790 800 810 820 830 840
DLNESNSQST RGIKSSVRYK FLNNVSQKDK SKIKLENIDP DGLPKIGSQL TKGKPELCIF
850 860 870 880 890 900
DTLKRGAKLS KFKDSEKARI ETVRVCGNDD KNPDNLSIGY TIRYSRIPVI GDKFSSRHGQ
910 920 930 940 950 960
KGVLSVLWPQ VDMPFTENGI TPDLIINPHA FPSRMTMGML IQSMAAKSGS LRGEFKTVET
970 980 990 1000 1010 1020
FQRYDDNDIV GHFGKELLDK GFNYHGNELM YSGIFGTPLK ADIFIGVVYY QRLRHMVSDK
1030 1040 1050 1060 1070 1080
SQARGTGPID ILTHQPVKGR KKGGGIRFGE MERDSLLAHG AAYCLNDRLF RSSDYSEGFV
1090 1100 1110 1120 1130 1140
CQNCGSILSC YVNRAIMKTQ TFIPPSLDES NKDTEDKEIH MNEKVICKVC KKNSNCKKVA
1150 1160
LPFVLRFLAN ELASMGIKLK FTVNDF