Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P28287
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P28287-F1 | Predicted | AlphaFoldDB |
No variants for P28287
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P28287 | |||||
No associated diseases with P28287
1 regional properties for P28287
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | TATA-box binding protein, conserved site | 136 - 185 | IPR030491 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| microtubule-based process | Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MREVISIHVG | QAGIQVGNAC | WELFCLEHGI | QPDGQMPSDK | TIGGGDDAFN | TFFSETGAGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HVPRCVFLDL | EPTVDDEVRT | GTYRQLFHPE | QLISGKEDAA | NNFARGHYTI | GKEIVDLCLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIRKLADQCT | GLQGFLVFNS | VGGGTGSGLG | SLLLERLSVD | YGKKSKLGFT | VYPSPQVSTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVEPYNSVLS | THSLLEHTDV | AVMLDNEAVY | DICRRNLDIE | RPTYTNLNRL | IAQVISSLTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLRFDGALNV | DVTEFQTNLV | PYPRIHFMLS | SYAPVISAEK | AYHEQLSVAE | ITNSAFEPAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MMAKCDPRHG | KYMACCLMYR | GDVVPKDVNA | AVATIKTKRT | IQFVDWCPTG | FKCGINYQPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVVPGGDLAK | VMRAVCMISN | STAIAEVFSR | IDHKFDLMYA | KRAFVHWYVG | EGMEEGEFSE |
| 430 | 440 | ||||
| AREDLAALEK | DYEEVGIETA | EGEGEEEGME |