P28272
Gene name |
URA1 (YKL216W) |
Protein name |
Dihydroorotate dehydrogenase (fumarate) |
Names |
DHOD, DHODase, DHOdehase, Dihydroorotate oxidase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL216W |
EC number |
1.3.98.1: With other, known, acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P28272
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P28272-F1 | Predicted | AlphaFoldDB |
4 variants for P28272
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-25387 | 58 | E>K | strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 413, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17 [UniProt] | No | SGRP |
| s11-25408 | 65 | P>S | No | SGRP | |
| s11-25988 | 258 | K>R | No | SGRP | |
| s11-26137 | 308 | R>S | No | SGRP |
No associated diseases with P28272
3 regional properties for P28272
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Dihydroorotate dehydrogenase, conserved site | 41 - 60 | IPR001295-1 |
| conserved_site | Dihydroorotate dehydrogenase, conserved site | 248 - 268 | IPR001295-2 |
| domain | Dihydroorotate dehydrogenase domain | 5 - 308 | IPR005720 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.98.1 | With other, known, acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| dihydroorotate dehydrogenase (fumarate) activity | Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate. |
| dihydroorotate dehydrogenase activity | Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' pyrimidine nucleobase biosynthetic process | The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. |
| 'de novo' UMP biosynthetic process | The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTASLTTKFL | NNTYENPFMN | ASGVHCMTTQ | ELDELANSKA | GAFITKSATT | LEREGNPEPR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YISVPLGSIN | SMGLPNEGID | YYLSYVLNRQ | KNYPDAPAIF | FSVAGMSIDE | NLNLLRKIQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEFNGITELN | LSCPNVPGKP | QVAYDFDLTK | ETLEKVFAFF | KKPLGVKLPP | YFDFAHFDIM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKILNEFPLA | YVNSINSIGN | GLFIDVEKES | VVVKPKNGFG | GIGGEYVKPT | ALANVRAFYT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLRPEIKVIG | TGGIKSGKDA | FEHLLCGASM | LQIGTELQKE | GVKIFERIEK | ELKDIMEAKG |
| 310 | |||||
| YTSIDQFRGK | LNSI |