P27988

PR
Gene name
Protein name
Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha
Names
ACS subunit, Acetyl-CoA synthase subunit, CODH/ACS
Species
Moorella thermoacetica (Clostridium thermoaceticum)
KEGG Pathway
EC number
2.3.1.169: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

454-524 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P27988

Entry ID Method Resolution Chain Position Source
1MJG X-ray 220 A M/N/O/P 1-729 PDB
1OAO X-ray 190 A C/D 1-729 PDB
2Z8Y X-ray 251 A M/N/O/P 1-729 PDB
3GIT X-ray 300 A A/B/C/D/E/F 311-729 PDB
3I01 X-ray 215 A M/N/O/P 1-729 PDB
3I04 X-ray 215 A M/N/O/P 2-729 PDB
3S2X X-ray 235 A A/B 594-729 PDB
5GOL X-ray 211 A A/B/C/D 594-728 PDB
5H6W X-ray 220 A A/B/C/D 594-728 PDB
6X5K X-ray 247 A M/N/O/P 1-729 PDB
AF-P27988-F1 Predicted AlphaFoldDB

No variants for P27988

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27988

No associated diseases with P27988

2 regional properties for P27988

Type Name Position InterPro Accession
domain Carbon monoxide dehydrogenase subunit alpha,N-terminal 38 - 119 IPR041350
domain CO dehydrogenase/acetyl-CoA synthase complex beta subunit, C-terminal 485 - 729 IPR045822

Functions

Description
EC Number 2.3.1.169 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
carbon-monoxide dehydrogenase (acceptor) activity Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor.
CO-methylating acetyl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
acetyl-CoA metabolic process The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDFDKIFEG AIPEGKEPVA LFREVYHGAI TATSYAEILL NQAIRTYGPD HPVGYPDTAY
70 80 90 100 110 120
YLPVIRCFSG EEVKKLGDLP PILNRKRAQV SPVLNFENAR LAGEATWYAA EIIEALRYLK
130 140 150 160 170 180
YKPDEPLLPP PWTGFIGDPV VRRFGIKMVD WTIPGEAIIL GRAKDSKALA KIVKELMGMG
190 200 210 220 230 240
FMLFICDEAV EQLLEENVKL GIDYIAYPLG NFTQIVHAAN YALRAGMMFG GVTPGAREEQ
250 260 270 280 290 300
RDYQRRRIRA FVLYLGEHDM VKTAAAFGAI FTGFPVITDQ PLPEDKQIPD WFFSVEDYDK
310 320 330 340 350 360
IVQIAMETRG IKLTKIKLDL PINFGPAFEG ESIRKGDMYV EMGGNRTPAF ELVRTVSESE
370 380 390 400 410 420
ITDGKIEVIG PDIDQIPEGS KLPLGILVDI YGRKMQADFE GVLERRIHDF INYGEGLWHT
430 440 450 460 470 480
GQRNINWLRV SKDAVAKGFR FKNYGEILVA KMKEEFPAIV DRVQVTIFTD EAKVKEYMEV
490 500 510 520 530 540
AREKYKERDD RMRGLTDETV DTFYSCVLCQ SFAPNHVCIV TPERVGLCGA VSWLDAKASY
550 560 570 580 590 600
EINHAGPNQP IPKEGEIDPI KGIWKSVNDY LYTASNRNLE QVCLYTLMEN PMTSCGCFEA
610 620 630 640 650 660
IMAILPECNG IMITTRDHAG MTPSGMTFST LAGMIGGGTQ TPGFMGIGRT YIVSKKFISA
670 680 690 700 710 720
DGGIARIVWM PKSLKDFLHD EFVRRSVEEG LGEDFIDKIA DETIGTTVDE ILPYLEEKGH
PALTMDPIM