P27818

PR
Gene name
Protein name
Acetolactate synthase 1, chloroplastic
Names
ALS I, Acetohydroxy-acid synthase I, Acetolactate synthase I
Species
Brassica napus (Rape)
KEGG Pathway
bna:106366634
EC number
2.2.1.6: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27818

Entry ID Method Resolution Chain Position Source
AF-P27818-F1 Predicted AlphaFoldDB

No variants for P27818

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27818

No associated diseases with P27818

5 regional properties for P27818

Type Name Position InterPro Accession
conserved_site TPP-binding enzyme, conserved site 506 - 525 IPR000399
domain Thiamine pyrophosphate enzyme, TPP-binding 469 - 624 IPR011766
domain Thiamine pyrophosphate enzyme, central domain 276 - 405 IPR012000
domain Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 83 - 246 IPR012001
domain Acetolactate synthase large subunit, TPP binding domain 447 - 639 IPR039368

Functions

Description
EC Number 2.2.1.6 Transketolases and transaldolases
Subcellular Localization
  • Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

4 GO annotations of molecular function

Name Definition
acetolactate synthase activity Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

3 GO annotations of biological process

Name Definition
isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
response to herbicide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
valine biosynthetic process The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAATSSSPI SLTAKPSSKS PLPISRFSLP FSLTPQKDSS RLHRPLAISA VLNSPVNVAP
70 80 90 100 110 120
PSPEKTDKNK TFVSRYAPDE PRKGADILVE ALERQGVETV FAYPGGASME IHQALTRSST
130 140 150 160 170 180
IRNVLPRHEQ GGVFAAEGYA RSSGKPGICI ATSGPGATNL VSGLADAMLD SVPLVAITGQ
190 200 210 220 230 240
VPRRMIGTDA FQETPIVEVT RSITKHNYLV MDVDDIPRIV QEAFFLATSG RPGPVLVDVP
250 260 270 280 290 300
KDIQQQLAIP NWDQPMRLPG YMSRLPQPPE VSQLGQIVRL ISESKRPVLY VGGGSLNSSE
310 320 330 340 350 360
ELGRFVELTG IPVASTLMGL GSYPCNDELS LQMLGMHGTV YANYAVEHSD LLLAFGVRFD
370 380 390 400 410 420
DRVTGKLEAF ASRAKIVHID IDSAEIGKNK TPHVSVCGDV KLALQGMNKV LENRAEELKL
430 440 450 460 470 480
DFGVWRSELS EQKQKFPLSF KTFGEAIPPQ YAIQILDELT EGKAIISTGV GQHQMWAAQF
490 500 510 520 530 540
YKYRKPRQWL SSSGLGAMGF GLPAAIGASV ANPDAIVVDI DGDGSFIMNV QELATIRVEN
550 560 570 580 590 600
LPVKILLLNN QHLGMVMQWE DRFYKANRAH TYLGDPAREN EIFPNMLQFA GACGIPAARV
610 620 630 640 650
TKKEELREAI QTMLDTPGPY LLDVICPHQE HVLPMIPSGG TFKDVITEGD GRTKY