P27809
Gene name |
KRE2 (MNT1, YDR483W, D8035.26) |
Protein name |
Glycolipid 2-alpha-mannosyltransferase |
Names |
Alpha-1,2-mannosyltransferase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR483W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P27809
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1S4N | X-ray | 201 A | A/B | 97-442 | PDB |
| 1S4O | X-ray | 201 A | A/B | 97-442 | PDB |
| 1S4P | X-ray | 201 A | A/B | 97-442 | PDB |
| AF-P27809-F1 | Predicted | AlphaFoldDB |
18 variants for P27809
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1421266 | 40 | I>V | No | SGRP | |
|
s04-1421278 s04-1421280 |
44 | F>L | No | SGRP | |
| s04-1421299 | 51 | I>V | No | SGRP | |
| s04-1421317 | 57 | V>F | No | SGRP | |
| s04-1421368 | 74 | S>A | No | SGRP | |
| s04-1421378 | 77 | S>N | No | SGRP | |
| s04-1421551 | 135 | K>Q | No | SGRP | |
| s04-1421564 | 139 | S>N | No | SGRP | |
| s04-1421588 | 147 | K>R | No | SGRP | |
| s04-1421900 | 251 | K>R | No | SGRP | |
| s04-1421946 | 266 | E>D | No | SGRP | |
| s04-1421971 | 275 | V>I | No | SGRP | |
| s04-1421993 | 282 | V>A | No | SGRP | |
| s04-1422074 | 309 | S>N | No | SGRP | |
| s04-1422085 | 313 | N>D | No | SGRP | |
| s04-1422442 | 432 | V>I | No | SGRP | |
| s04-1422468 | 440 | F>L | No | SGRP | |
| s04-1422472 | 442 | E>Q | No | SGRP |
No associated diseases with P27809
No regional properties for P27809
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P27809 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi medial cisterna | The middle Golgi cisterna (or cisternae). |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-1,2-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall mannoprotein biosynthetic process | The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. |
| mannosylation | The covalent attachment of a mannose residue to a substrate molecule. |
| N-glycan processing | The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. |
| protein N-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
| protein O-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P27810 | KTR1 | Alpha-1,2 mannosyltransferase KTR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALFLSKRLL | RFTVIAGAVI | VLLLTLNSNS | RTQQYIPSSI | SAAFDFTSGS | ISPEQQVISE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENDAKKLEQS | ALNSEASEDS | EAMDEESKAL | KAAAEKADAP | IDTKTTMDYI | TPSFANKAGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKACYVTLVR | NKELKGLLSS | IKYVENKINK | KFPYPWVFLN | DEPFTEEFKE | AVTKAVSSEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KFGILPKEHW | SYPEWINQTK | AAEIRADAAT | KYIYGGSESY | RHMCRYQSGF | FWRHELLEEY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DWYWRVEPDI | KLYCDINYDV | FKWMQENEKV | YGFTVSIHEY | EVTIPTLWQT | SMDFIKKNPE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLDENNLMSF | LSNDNGKTYN | LCHFWSNFEI | ANLNLWRSPA | YREYFDTLDH | QGGFFYERWG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DAPVHSIAAA | LFLPKDKIHY | FSDIGYHHPP | YDNCPLDKEV | YNSNNCECDQ | GNDFTFQGYS |
| 430 | 440 | ||||
| CGKEYYDAQG | LVKPKNWKKF | RE |