P27738

PR
Gene name
Protein name
RNA-directed RNA polymerase
Names
216.5 kDa protein, ORF1 protein, RNA replicase
Species
Apple chlorotic leaf spot virus (isolate plum P863) (ACLSV)
KEGG Pathway
vg:1493999
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P27738

Entry ID Method Resolution Chain Position Source

6 variants for P27738

Variant ID(s) Position Change Description Diseaes Association Provenance
347 I>V No
591 A>P No
594 S>L No
666 D>R No
1598 Y>H No
1623 E>K No

No associated diseases with P27738

6 regional properties for P27738

Type Name Position InterPro Accession
domain RNA-dependent RNA polymerase, alsuviricetes 1470 - 1785 IPR001788
domain Alphavirus-like methyltransferase (MT) domain 43 - 336 IPR002588
domain Oxoglutarate/iron-dependent dioxygenase 747 - 835 IPR005123
domain RNA-directed RNA polymerase, catalytic domain 1633 - 1740 IPR007094
domain RNA-directed RNA polymerase, apple chlorotic leaf spot virus 843 - 934 IPR008744
domain (+) RNA virus helicase core domain 1032 - 1336 IPR027351

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAFSYRTPQE ELLSRLPQSQ QEVISGFQYE RIQKEEEKKV ENFSFYLPEK TREWFTKSGV
70 80 90 100 110 120
YLSPFAYVNH SHPGCKTLEN HLLFNVVASY ISKYSYVACL SIKSNKMSKM ERLGPNSVKT
130 140 150 160 170 180
YDILNRLVTA KDKARYGPLA KPERSPCPKK TNIFIHDEIH YWSRDQLETF LQVHRPKNLW
190 200 210 220 230 240
ATLVFPPEIL AGYKSSVLPF LYQFEIHGKD LVYMPDGVRS ESYTQPLENG FLLSSSSIII
250 260 270 280 290 300
KNRVTGVEIR YQVSLVYSLG SHHLFHIYPA EDLMKEEVRR FGPYDLFDVG SLFVKPVRVP
310 320 330 340 350 360
IQDFPLSVFK KIFIYMSSLK KPDVQSAVAK LRQLSDADIS IESVFMIQEF ASRIEKNGVE
370 380 390 400 410 420
SWSCSFWGCM KDWFFDKLPY REVLEKIGLA DDFTRRLMKI KPLAFDIHTT DRPLTVRMII
430 440 450 460 470 480
DQIWEERLSS FDNISNIVFY GRREWLNNGV LPKVKKKGLA KLIPGREVDS HNYPREIYSD
490 500 510 520 530 540
LLSSTSIWRS YDDDFRHRSA SPLVILRSNR AYSEAAKFSS NCLSLCAAPC DEVIARTPFE
550 560 570 580 590 600
LNHRREKKEL SLKCLDFHIK KMKVKNVLEL EVKLRERNTR ISLSKKGVKK AGRSRMIPVH
610 620 630 640 650 660
LLKPTCGEGN GKPEERNKEE AKIPMNEGTS KEEKGSEPPH SEVKREGVRL DEQHISEPLL
670 680 690 700 710 720
SFKLDDFVGR EKLCSAGLIK TVGNDYLLLA RQIECMPLSQ LRGKKAAYFC LDFPMVYFHD
730 740 750 760 770 780
KVSYPTFEAT GEIRHVMMKA RSKWGIDFNS ALIQVYNDGC RLPLHSDNEE CYDDDGILTI
790 800 810 820 830 840
NVVGDAKFHT TCHDEVIDLK QGNEILMPAG YQKKNRHAVE VASEGRTSVT LRVHKRDFSF
850 860 870 880 890 900
ESKLRFIKGK FDCLFVSVAE IIHKKPEEIM MFIPHIMDRC VSNRGCSLDD AKAICEKYEI
910 920 930 940 950 960
KIECEGDCGL VECGTSGLSI GRMLLRGNHF SVASVRRSSM DSLANSSKEI KSDGVLDHVT
970 980 990 1000 1010 1020
FNFHKRLKLV EPDLTNADIK VDSSRAGKLL KSLMDGMTGI VSHNSTHEGW RMIKGINSTS
1030 1040 1050 1060 1070 1080
EMRSFMNMVR GQIEEPKSDL FDKVQELNFM KVKIYGIFGF AGSGKSHAIQ NLIQTEFKGS
1090 1100 1110 1120 1130 1140
QGIMVICPRR FLAKDWSEKG VDEKDIKTFE SALKSDVKGK RLFILDEISL LPKGFTDLLM
1150 1160 1170 1180 1190 1200
LKMHMEGILK KSTIVCIGDP LQAGYFCPKD DNYLSREGEI KRLFKGGVNY KWYSYRINKF
1210 1220 1230 1240 1250 1260
IAKKLAIETM NDFIGIDEQS SIYKDMPSAH HFMEKKGNHI EVILVASMVE KELYSNYGNV
1270 1280 1290 1300 1310 1320
MTFGESQGLT FNCGVIVLSE EAKLCSDAHI MVAITRFRRG FCFALGSKGS KEDYMRSMKS
1330 1340 1350 1360 1370 1380
GLLQRICSGV GASKEFILGS SSVNLILSEK DIAKGAGIDE MDREARLEGD VWLKSMIYLG
1390 1400 1410 1420 1430 1440
KRYHMVEPLG QVIKLTDDAI KCHIPVCSSQ TLGPELDNIQ AREYREFKGK NGWSNQFREE
1450 1460 1470 1480 1490 1500
AGPNWKFPYK VNQAMSYEAV YPRHKMDDDL TFLAAIKKRL RFDNVANNYA KFKAAESRGK
1510 1520 1530 1540 1550 1560
YLTKIFLKHV PIKCGRDQRL LDQCRQEFEE TKLSKSAATI GAHSQRSDSD WPLDKIFLFM
1570 1580 1590 1600 1610 1620
KSQLCTKFEK RFTEAKAGQT LACFPHKILV EFSPWCRYTE KVLTANLPDN YYIHQRKNFS
1630 1640 1650 1660 1670 1680
ELEDFARRFS NGSICVESDY TAFDVSQDHT ILAFEVELLR HFGWDDRVLQ SYIKMKCTLG
1690 1700 1710 1720 1730 1740
CRLGGFAIMR FTGEFSTFLF NTLANMVFTF CRYEVPDGTP ICFAGDDMCA LRNLREIDTH
1750 1760 1770 1780 1790 1800
EFILSKLSLK AKVNRTKVPM FCGWRLCCDG LIKEPCLIYE RLQVAIENGR LMDVIDSYFL
1810 1820 1830 1840 1850 1860
EFSFAYKLGE RLYSHLEIEQ LNYHQVLTRF FIRNKHLLRG DSRHNISELE WLSDEDGDND
1870 1880
KGSQIEDRRR GYSNCWGEKL QNLF