P27616

PR
Gene name
ADE1 (YAR015W)
Protein name
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Names
85 kDa lysosomal membrane sialoglycoprotein, LGP85, CD36 antigen-like 2, Lysosome membrane protein II, LIMP II, Scavenger receptor class B member 2, SAICAR synthetase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YAR015W
EC number
6.3.2.6: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-212 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for P27616

Entry ID Method Resolution Chain Position Source
1A48 X-ray 190 A A 2-306 PDB
1OBD X-ray 140 A A 2-306 PDB
1OBG X-ray 205 A A 2-306 PDB
2CNQ X-ray 100 A A 2-306 PDB
2CNU X-ray 105 A A 2-306 PDB
2CNV X-ray 200 A A 2-306 PDB
AF-P27616-F1 Predicted AlphaFoldDB

3 variants for P27616

Variant ID(s) Position Change Description Diseaes Association Provenance
s01-169412 15 V>M No SGRP
s01-169608 80 A>V No SGRP
s01-170046 226 T>I No SGRP

No associated diseases with P27616

3 regional properties for P27616

Type Name Position InterPro Accession
conserved_site SAICAR synthetase, conserved site 114 - 128 IPR018236-1
conserved_site SAICAR synthetase, conserved site 213 - 221 IPR018236-2
domain SAICAR synthetase/ADE2, N-terminal 12 - 301 IPR028923

Functions

Description
EC Number 6.3.2.6 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.

2 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSITKTELDG ILPLVARGKV RDIYEVDAGT LLFVATDRIS AYDVIMENSI PEKGILLTKL
70 80 90 100 110 120
SEFWFKFLSN DVRNHLVDIA PGKTIFDYLP AKLSEPKYKT QLEDRSLLVH KHKLIPLEVI
130 140 150 160 170 180
VRGYITGSAW KEYVKTGTVH GLKQPQGLKE SQEFPEPIFT PSTKAEQGEH DENISPAQAA
190 200 210 220 230 240
ELVGEDLSRR VAELAVKLYS KCKDYAKEKG IIIADTKFEF GIDEKTNEII LVDEVLTPDS
250 260 270 280 290 300
SRFWNGASYK VGESQDSYDK QFLRDWLTAN KLNGVNGVKM PQDIVDRTRA KYIEAYETLT
GSKWSH