AiPD: Autoinhibited Protein Database

Gene name	pyp1 (SPAC26F1.10c)
Protein name	Tyrosine-protein phosphatase 1
Names	Protein-tyrosine phosphatase 1, PTPase 1
Species	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway	spo:SPAC26F1.10c
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-56 (Predicted disordered autoinhibitory region) PR

1-56 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P27574-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
I_5161644_C_A	45	L>I	No	Jeffares_SNPs
I_5161693_C_A	61	P>H	No	Jeffares_SNPs
I_5161911_G_A	134	G>S	No	Jeffares_SNPs
I_5161924_G_A	138	R>K	No	Jeffares_SNPs
I_5161977_G_A	156	V>I	No	Jeffares_SNPs
I_5162041_C_A	177	P>H	No	Jeffares_SNPs
I_5162049_C_A,T	180	R>C	No	Jeffares_SNPs
I_5162050_G_A	180	R>H	No	Jeffares_SNPs
I_5162049_C_A,T	180	R>S	No	Jeffares_SNPs
I_5162196_G_A	229	D>N	No	Jeffares_SNPs
I_5162279_T_G	256	D>E	No	Jeffares_SNPs
I_5162394_T_A	295	S>T	No	Jeffares_SNPs
I_5162479_A_T	323	D>V	No	Jeffares_SNPs
I_5162665_G_A	385	S>N	No	Jeffares_SNPs
I_5162731_T_C	407	V>A	No	Jeffares_SNPs
I_5162782_T_C	424	F>S	No	Jeffares_SNPs
I_5162901_G_A	464	G>R	No	Jeffares_SNPs
I_5163021_T_C	504	S>P	No	Jeffares_SNPs
I_5163045_G_A	512	V>I	No	Jeffares_SNPs
I_5163113_C_A	534	D>E	No	Jeffares_SNPs
I_5163120_G_A	537	D>N	No	Jeffares_SNPs

Type	Name	Position	InterPro Accession
domain	Tyrosine-specific protein phosphatase, PTPase domain	259 - 541	IPR000242
domain	Tyrosine-specific protein phosphatases domain	451 - 530	IPR000387
domain	Rhodanese-like domain	43 - 103	IPR001763
domain	Protein-tyrosine phosphatase, catalytic	429 - 538	IPR003595
active_site	Protein-tyrosine phosphatase, active site	468 - 478	IPR016130

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein aggregate center	Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.

Name	Definition
MAP kinase tyrosine phosphatase activity	Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Name	Definition
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
negative regulation of p38MAPK cascade	Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
regulation of stress-activated MAPK cascade	Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins