P27526
Gene name |
phr (NCU08626) |
Protein name |
Deoxyribodipyrimidine photo-lyase |
Names |
DNA photolyase, Photoreactivating enzyme |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU08626 |
EC number |
4.1.99.3: Other carbon-carbon lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P27526
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P27526-F1 | Predicted | AlphaFoldDB |
No variants for P27526
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P27526 | |||||
No associated diseases with P27526
6 regional properties for P27526
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 162 - 292 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 294 - 412 | IPR000595-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 190 - 206 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 238 - 255 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 321 - 337 | IPR018488-3 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 359 - 376 | IPR018488-4 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.99.3 | Other carbon-carbon lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| deoxyribodipyrimidine photo-lyase activity | Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| FAD binding | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| response to light stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPSKRKASA | PPQTSHVNGN | PSADKKRKTT | TDAPPTNPNT | SSDPLRAPHP | FYKDSETHGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLRKFYPHEM | SNARAQAYND | NELPRPIETL | SAALAETAAL | RKSLPVRQAV | VHWFKMDLRL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HDNRSLWLAS | QKAKEAGVPL | ICLYVLSPED | LEAHLRAPIR | VDFMLRTLEV | LKTDLEDLGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLWVETVEKR | KEVPTKIKEL | MKSWGASHLF | CAMEYEVDEL | RREAKLVKLL | AEGEKGEKMA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADVVHDTCVV | MPGALQSGSG | GQYAVYSPWF | RAWIKHIEEN | PECLEIYEKP | GPNPPGTKEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HENLFACSIP | EAPEGKRLRD | DEKARYHSLW | PAGEHEALKR | LEKFCDEAIG | KYAERRNIPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MQGTSNLSVH | FASGTLSART | AIRTARDRNN | TKKLNGGNEG | IQRWISEVAW | RDFYKHVLVH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WPYVCMNKPF | KPTYSNIEWS | YNVDHFHAWT | QGRTGFPIID | AAMRQVLSTG | YMHNRLRMIV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ASFLAKDLLV | DWRMGERYFM | EHLIDGDFAS | NNGGWGFAAS | VGVDPQPYFR | VFNPLLQSEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FDPDGDYIRK | WVEELRDLPE | LKGGKGGEIH | DPYGRGSEKV | KKKLEEKGYP | RPIVEHSGAR |
| 610 | |||||
| DRALDAYKRG | LARDL |