P27401

PR
Gene name
pol
Protein name
Pro-Pol polyprotein
Names
Pr125Pol
Species
Simian foamy virus type 3 (strain LK3) (SFVagm) (SFV-3)
KEGG Pathway
vg:6386654
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

124-202 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P27401

Entry ID Method Resolution Chain Position Source

No variants for P27401

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27401

No associated diseases with P27401

6 regional properties for P27401

Type Name Position InterPro Accession
domain Reverse transcriptase domain 186 - 363 IPR000477
domain Integrase, catalytic core 864 - 1023 IPR001584
domain Spumavirus aspartic protease A9 1 - 176 IPR001641
domain Ribonuclease H domain 590 - 748 IPR002156
domain Retroviral integrase, C-terminal SH3 domain 1063 - 1125 IPR040903
domain Integrase zinc-binding domain 799 - 854 IPR041588

Functions

Description
EC Number
Subcellular Localization
  • [Integrase]: Virion
  • Host nucleus
  • Host cytoplasm
  • Nuclear at initial phase, cytoplasmic at assembly
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

6 GO annotations of molecular function

Name Definition
aspartic-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
metal ion binding Binding to a metal ion.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

7 GO annotations of biological process

Name Definition
DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
establishment of integrated proviral latency A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
viral genome integration into host DNA The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses.
viral penetration into host nucleus The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDPLQLLQPL EAEIKGTKLK AHWDSGATIT CVPQAFLEEE VPIKNIWIKT IHGEKEQPVY
70 80 90 100 110 120
YLTFKIQGRK VEAEVISSPY DYILVSPSDI PWLMKKPLQL TTLVPLQEYE ERLLKQTMLT
130 140 150 160 170 180
GSYKEKLQSL FLKYDALWQH WENQVGHRRI KPHHIATGTV NPRPQKQYPI NPKAKASIQT
190 200 210 220 230 240
VINDLLKQGV LIQQNSIMNT PVYPVPKPDG KWRMVLDYRE VNKTIPLIAA QNQHSAGILS
250 260 270 280 290 300
SIFRGKYKTT LDLSNGFWAH SITPESYWLT AFTWLGQQYC WTRLPQGFLN SPALFTADVV
310 320 330 340 350 360
DLLKEVPNVQ VYVDDIYISH DDPREHLEQL EKVFSLLLNA GYVVSLKKSE IAQHEVEFLG
370 380 390 400 410 420
FNITKEGRGL TETFKQKLLN ITPPRDLKQL QSILGLLNFA RNFIPNFSEL VKPLYNIIAT
430 440 450 460 470 480
ANGKYITWTT DNSQQLQNII SMLNSAENLE ERNPEVRLIM KVNTSPSAGY IRFYNEFAKR
490 500 510 520 530 540
PIMYLNYVYT KAEVKFTNTE KLLTTIHKGL IKALDLGMGQ EILVYSPIVS MTKIQKTPLP
550 560 570 580 590 600
ERKALPIRWI TWMSYLEDPR IQFHYDKTLP ELQQVPTVTD DIIAKIKHPS EFSMVFYTDG
610 620 630 640 650 660
SAIKHPNVNK SHNAGMGIAQ VQFKPEFTVI NTWSIPLGDH TAQLAEVAAV EFACKKALKI
670 680 690 700 710 720
DGPVLIVTDS FYVAESVNKE LPYWQSNGFF NNKKKPLKHV SKWKSIADCI QLKPDIIIIH
730 740 750 760 770 780
EKGHQPTAST FHTEGNNLAD KLATQGSYVV NINTTPSLDA ELDQLLQGQY PKGFPKHYQY
790 800 810 820 830 840
QLENGQVMVT RPNGKRIIPP KSDRPQIILQ AHNIAHTGRD STFLKVSSKY WWPNLRKDVV
850 860 870 880 890 900
KVIRQCKQCL VTNAATLAAP PILRPERPVK PFDKFFIDYI GPLPPSNGYL HVLVVVDSMT
910 920 930 940 950 960
GFVWLYPTKA PSTSATVKAL NMLTSIAVPK VIHSDQGAAF TSATFADWAK NKGIQLEFST
970 980 990 1000 1010 1020
PYHPQSSGKV ERKNSDIKRL LTKLLVGRPA KWYDLLPVVQ LALNNSYSPS SKYTPHQLLF
1030 1040 1050 1060 1070 1080
GIDSNTPFAN SDTLDLSREE ELSLLQEIRS SLYLPSTPPA SIRAWSPSVG QLVQERVARP
1090 1100 1110 1120 1130 1140
ASLRPRWHKP TPVLEVINPR AVVILDHLGN RRTVSVDNLK LTAYQKDGTP NESAAVVAME
KDE