P27112

PR
Gene name
ATP4A
Protein name
Potassium-transporting ATPase alpha chain 1
Names
Gastric H(+)/K(+) ATPase subunit alpha, Proton pump
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009279
EC number
7.2.2.19: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27112

Entry ID Method Resolution Chain Position Source
AF-P27112-F1 Predicted AlphaFoldDB

No variants for P27112

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27112

No associated diseases with P27112

5 regional properties for P27112

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 53 - 127 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 810 - 1019 IPR006068
domain Gastric H+/K+-transporter P-type ATPase, N-terminal 2 - 43 IPR015127
ptm P-type ATPase, phosphorylation site 387 - 393 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 366 - 778 IPR044492

Functions

Description
EC Number 7.2.2.19 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Apical cell membrane; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Localized in the apical canalicular membrane of parietal cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
magnesium ion binding Binding to a magnesium (Mg) ion.
P-type potassium:proton transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).
potassium ion binding Binding to a potassium ion (K+).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKADNYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA
70 80 90 100 110 120
ELEQKYQTSA TKGLSARLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA
130 140 150 160 170 180
ICLIAFAIQA SEGDLTTDDN LYLALALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA
190 200 210 220 230 240
TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP
250 260 270 280 290 300
ECTHESPLET RNIAFFSTMC LEGTAQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE
310 320 330 340 350 360
HFVDIIAGLA ILFGATFFVV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK
370 380 390 400 410 420
RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ
430 440 450 460 470 480
TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG
490 500 510 520 530 540
YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP
550 560 570 580 590 600
LDEQWREAFQ TAYLSLGGLG ERVLGFCHLY LSEKDYPPGY AFDVEAMNFP SSGLCFAGLV
610 620 630 640 650 660
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR
670 680 690 700 710 720
VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG
730 740 750 760 770 780
AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF
790 800 810 820 830 840
DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES
850 860 870 880 890 900
DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRPQ
910 920 930 940 950 960
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEMC QIADVLIRKT RRLSAFQQGF
970 980 990 1000 1010 1020
FRNRILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPMPFGLLI FVYDEIRKLG
1030
VRCCPGSWWD QELYY