P27088

PR
Gene name
xpa (xpac)
Protein name
DNA repair protein complementing XP-A cells homolog
Names
Xeroderma pigmentosum group A-complementing protein homolog
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:397790
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27088

Entry ID Method Resolution Chain Position Source
AF-P27088-F1 Predicted AlphaFoldDB

1 variants for P27088

Variant ID(s) Position Change Description Diseaes Association Provenance
3 P>del one isoform [UniProt] No

No associated diseases with P27088

3 regional properties for P27088

Type Name Position InterPro Accession
conserved_site Zinc finger, XPA-type, conserved site 97 - 127 IPR022652
domain XPA, C-terminal 129 - 180 IPR022656
conserved_site XPA, conserved site 132 - 148 IPR022658

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
DNA repair complex A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication factor A complex A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.
double-stranded DNA binding Binding to double-stranded DNA.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
UV-damage excision repair A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEPEPEPEQE ANKEEEKILS AAVRAKIERN RQRALMLRQA RLACRPYPTG EGISTVKAPP
70 80 90 100 110 120
KVIDSGGGFF IEEEEAEEQH VENVVRQPGP VLECDYLICE ECGKDFMDSY LSNHFDLAVC
130 140 150 160 170 180
DSCRDAEEKH KLITRTEAKQ EYLLKDCDID KREPVLKFIL KKNPHNTHWG DMKLYLKAQV
190 200 210 220 230 240
IKRSLEVWGS EEALEEAKEV RKDNRDKMKQ KKFDKKVKEL RRTVRSSLWK KEASGHQHEY
250 260
GPEEHVEEDS YKKTCITCGY EMNYEKM