P27045

PR
Gene name
gnai3
Protein name
Guanine nucleotide-binding protein G(i) subunit alpha-3
Names
G(i) alpha-3
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27045

Entry ID Method Resolution Chain Position Source
AF-P27045-F1 Predicted AlphaFoldDB

No variants for P27045

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27045

No associated diseases with P27045

No regional properties for P27045

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P27045

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Membrane ; Lipid-anchor
  • Localizes in the centrosomes of interphase and mitotic cells
  • Detected at the cleavage furrow and/or the midbody
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
G-protein beta/gamma-subunit complex binding Binding to a complex of G-protein beta/gamma subunits.
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding Binding to a metal ion.

5 GO annotations of biological process

Name Definition
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
dopamine receptor signaling pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
GTP metabolic process The chemical reactions and pathways involving GTP, guanosine triphosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
REAAERSKMI DRNLREDGEK ASKEVKLLLL GAGESGKSTI VKQMKIIHED GYSEEECRQY
70 80 90 100 110 120
KVVVYSNTIQ SIIAIIRAMG RLRIDFGDVA RADDARQLFV LASSAEEGVM SPELAGVIQR
130 140 150 160 170 180
LWEDSGVQAC FSRSREYQLN DSASYYLSDI ERIAQGSYIP TQQDVLRTRV KTTGIVETHF
190 200 210 220 230 240
TFKDLYFKMF DVGGQRSERK KWIHCFEGVT AIIFCVALSD YDLLLAEDEE MNRMHESMKL
250 260 270 280 290 300
FDSICNNKWF IDTSIILFLN KKDLFEEKIS RSPLTICYPE YSGSNTYEEA AAYIQCQFED
310 320 330 340
LNRRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKSNLM ECGLY