P27041

PR
Gene name
acvr2b
Protein name
Activin receptor type-2B
Names
Activin receptor type IIB, ACTR-IIB
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399277
EC number
2.7.11.30: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

96-215 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

337-362 (Activation loop from InterPro)

Target domain

189-477 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P27041

Entry ID Method Resolution Chain Position Source
AF-P27041-F1 Predicted AlphaFoldDB

No variants for P27041

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27041

No associated diseases with P27041

3 regional properties for P27041

Type Name Position InterPro Accession
domain Activin types I and II receptor domain 29 - 114 IPR000472
domain Protein kinase domain 189 - 477 IPR000719
active_site Serine/threonine-protein kinase, active site 316 - 328 IPR008271

Functions

Description
EC Number 2.7.11.30 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL VEGKKDKRLH
70 80 90 100 110 120
CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ VFFCCCEGNY CNKKFTHLPE
130 140 150 160 170 180
VETFDPKPQP SASVLNILIY SLLPIVGLSM AILLAFWMYR HRKPSYGHVE INEDPGLPPP
190 200 210 220 230 240
SPLVGLKPLQ LLDIKARGRF GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH
250 260 270 280 290 300
ENLLEFIAAE KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL
310 320 330 340 350 360
HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP PGDTHGQVGT
370 380 390 400 410 420
RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT AADGPVDEYL LPFEEEIGQH
430 440 450 460 470 480
PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERISQI
490 500 510
RKSVNGTTSD CLVSIVTSVT NVDLPPKESS I