P26752
Gene name |
fusA (fus, Ta0446) |
Protein name |
Elongation factor 2 |
Names |
EF-2 |
Species |
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) |
KEGG Pathway |
tac:Ta0446 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P26752
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P26752-F1 | Predicted | AlphaFoldDB |
No variants for P26752
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P26752 | |||||
No associated diseases with P26752
7 regional properties for P26752
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Elongation factor EFG, domain V-like | 622 - 709 | IPR000640 |
| domain | Translational (tr)-type GTP-binding domain | 19 - 257 | IPR000795 |
| domain | Translation elongation factor EFTu-like, domain 2 | 306 - 371 | IPR004161 |
| domain | Small GTP-binding protein domain | 22 - 154 | IPR005225 |
| domain | Translation elongation factor EFG/EF2, domain IV | 505 - 620 | IPR005517 |
| conserved_site | Tr-type G domain, conserved site | 60 - 75 | IPR031157 |
| domain | Elongation Factor G, domain II | 387 - 459 | IPR041095 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRKEDNIEK | ALKIVEHTEL | IRNIGIVAHI | DHGKTTLSDN | LIAGAGMMSE | ELAGKQLVLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YDEQEQARGI | TINAAVASMV | HTFQGKEYLI | NLIDTPGHVD | FGGDVTRAMR | AVDGVIVVVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVEGVMPQTE | TVIRQALREH | VKPVLFINKI | DRLINELRLN | SDEMQKRFTK | IITDVNRLIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KYAPQQFTKE | WQVSVQDGRV | AFGSAYNNWA | ISIPAMAETK | ITFKDIVEYV | KNGKQKELAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KNQLHKIILN | MVIRHLPDPK | TAQSYRIKQI | WKGDLDSEIG | KAMINCDYKG | PVAMMVTKII |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IDPHAGEIAI | GRLFSGTVKK | GTDLYISGAG | KGKVQTLAMM | VGPDRIPVDE | ITAGNIAAIV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLKGAIAGAT | VSSLENMVPF | EPMIHYSEPV | VTLAIEAKHT | ADLPRLIEVL | RDISKADPSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QVDINQETGE | HLISGMGELH | LDVTLYRIKN | DYKVEVETSD | PIVVYRETVE | KKGGPFEGKS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PNKHNRFYFE | VEPLKPEVIQ | AIEDGDIPQG | SKFKDKKALV | ELLVSKGIDR | DEAKGLVCVE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GTNMMFDVTR | GIQYLDETME | LLIEAFVEVM | NRGPLANEKV | FGVKARLVDA | KLHEDSIHRG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PAQVIPAGRN | SIYGAMCEAK | RVLLEPVQRV | FINVPQEEMG | AAINEIQQRR | GIIEDMKQEG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DEISLTAKVP | VAGMFGFASA | IRGATGGKVL | WSFENAGYQK | VPPELQDSIV | RSIRERKGLR |
| 730 | |||||
| QEPYDADYYA | SM |