P26675
Gene name |
Sos (CG7793) |
Protein name |
Protein son of sevenless |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
dme:Dmel_CG7793 |
EC number |
3.1.4.53: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q08499)
PDE4D encodes a cAMP-specific 3',5'-cyclic phosphodiesterase 4D involved in the hydrolysis of cAMP and cGMP, which play important roles in many physiological processes. The autoinhibitory domain of PDE4D is located in the upstream conserved region 2 (UCR2) that inhibits PDE4D activity. Specifically, the α-helical NQVSE[F/Y]ISXTFLD sequence within UCR2 can fold across the catalytic pocket and thus control access to it. In addition, UCR1 can interact with UCR2 to regulate the activity of PDE4.
Autoinhibitory domains (AIDs)
Target domain |
825-1067 (Ras guanine-nucleotide exchange factors catalytic domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
825-1067 (Ras guanine-nucleotide exchange factors catalytic domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
- Tartaglia M et al. (2010) "Noonan syndrome: clinical aspects and molecular pathogenesis", Molecular syndromology, 1, 2-26
- Sondermann H et al. (2004) "Structural analysis of autoinhibition in the Ras activator Son of sevenless", Cell, 119, 393-405
- Gureasko J et al. (2010) "Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless", Proceedings of the National Academy of Sciences of the United States of America, 107, 3430-5
Autoinhibited structure
Activated structure
2 structures for P26675
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1AZE | NMR | - | B | 1342-1350 | PDB |
| AF-P26675-F1 | Predicted | AlphaFoldDB |
3 variants for P26675
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 1256 | P>L | strain: St_L028 and St_L033 [UniProt] | No | ||
| 1322 | A>S | strain: In_L019 [UniProt] | No | ||
| 1503 | S>N | strain: In_L019 [UniProt] | No |
No associated diseases with P26675
4 regional properties for P26675
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 178 - 507 | IPR002073 |
| domain | HD/PDEase domain | 251 - 435 | IPR003607 |
| conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 294 - 305 | IPR023174 |
| domain | Phosphodiesterase 4 upstream conserved regions (UCR) | 19 - 135 | IPR040844 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.53 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| rhabdomere microvillus membrane | The portion of the plasma membrane surrounding a microvillus of a rhabdomere. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| axon midline choice point recognition | The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline. |
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| epidermal growth factor receptor signaling pathway | The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| epithelial cell migration, open tracheal system | The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster. |
| fibroblast growth factor receptor signaling pathway | The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. |
| imaginal disc-derived leg morphogenesis | The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster. |
| negative regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| photoreceptor cell fate determination | The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed. |
| positive regulation of cell size | Any process that increases cell size. |
| positive regulation of Rac protein signal transduction | Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction. |
| positive regulation of Ras protein signal transduction | Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. |
| R7 cell fate commitment | The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
| sevenless signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| torso signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| tracheal outgrowth, open tracheal system | The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster. |
| vascular endothelial growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6N9I4 | RASGRP2 | RAS guanyl-releasing protein 2 | Bos taurus (Bovine) | SS |
| Q1LZ97 | RASGRP4 | RAS guanyl-releasing protein 4 | Bos taurus (Bovine) | SS |
| A0A3S5ZPR1 | RASGRP3 | RAS guanyl releasing protein 3 | Gallus gallus (Chicken) | SS |
| Q5JS13 | RALGPS1 | Ras-specific guanine nucleotide-releasing factor RalGPS1 | Homo sapiens (Human) | PR |
| O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | Homo sapiens (Human) | EV |
| Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | Homo sapiens (Human) | EV SS |
| Q86X27 | RALGPS2 | Ras-specific guanine nucleotide-releasing factor RalGPS2 | Homo sapiens (Human) | PR |
| Q8IV61 | RASGRP3 | Ras guanyl-releasing protein 3 | Homo sapiens (Human) | SS |
| Q8TDF6 | RASGRP4 | RAS guanyl-releasing protein 4 | Homo sapiens (Human) | SS |
| Q13905 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | Homo sapiens (Human) | PR |
| Q07890 | SOS2 | Son of sevenless homolog 2 | Homo sapiens (Human) | SS |
| Q07889 | SOS1 | Son of sevenless homolog 1 | Homo sapiens (Human) | EV |
| A2AR50 | Ralgps1 | Ras-specific guanine nucleotide-releasing factor RalGPS1 | Mus musculus (Mouse) | PR |
| Q8BTM9 | Rasgrp4 | RAS guanyl-releasing protein 4 | Mus musculus (Mouse) | SS |
| Q9Z1S3 | Rasgrp1 | RAS guanyl-releasing protein 1 | Mus musculus (Mouse) | SS |
| Q9QUG9 | Rasgrp2 | RAS guanyl-releasing protein 2 | Mus musculus (Mouse) | SS |
| Q9ERD6 | Ralgps2 | Ras-specific guanine nucleotide-releasing factor RalGPS2 | Mus musculus (Mouse) | PR |
| Q02384 | Sos2 | Son of sevenless homolog 2 | Mus musculus (Mouse) | SS |
| Q62245 | Sos1 | Son of sevenless homolog 1 | Mus musculus (Mouse) | SS |
| Q9R1K8 | Rasgrp1 | RAS guanyl-releasing protein 1 | Rattus norvegicus (Rat) | SS |
| P0C643 | Rasgrp2 | RAS guanyl-releasing protein 2 | Rattus norvegicus (Rat) | SS |
| Q8R5I4 | Rasgrp4 | RAS guanyl-releasing protein 4 | Rattus norvegicus (Rat) | SS |
| Q9N5D3 | sos-1 | Son of sevenless homolog | Caenorhabditis elegans | EV |
| A4IJ06 | rasgrp1 | RAS guanyl-releasing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| NSSRTSSAAS | DLHGEDMIVT | PFAQVLASLR | TVRSNVAALA | HGAGSATRQA | LLGTPPQSSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QAAPAEESGL | QLAQETLEEL | DWCLEQLETL | QTRRSVGEMA | SNKFKRMLNR | ELTHLSETSR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGNQVSEYIS | QTFLDQQAEV | ELPAPPTEDH | PWPMAQITGL | RKSCHTSLPT | AAIPRFGVQT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DQEEQLAKEL | EDTNKWGLDV | FKVAELSGNR | PLTAVIFRVL | QERDLLKTFQ | IPADTLLRYL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTLEGHYHSN | VAYHNSIHAA | DVVQSAHVLL | GTPALEAVFT | DLEVLAAIFA | CAIHDVDHPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSNQFLINTN | SELALMYNDS | SVLENHHLAV | GFKLLQGENC | DIFQNLSTKQ | KLSLRRMVID |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MVLATDMSKH | MSLLADLKTM | VETKKVTSLG | VLLLDNYSDR | IQVLQSLVHC | ADLSNPAKPL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PLYRQWTERI | MAEFFQQGDR | ERESGLDISP | MCDKHTASVE | KSQVGFIDYI | AHPLWETWAD |
| 490 | 500 | 510 | 520 | 530 | |
| LVHPDAQELL | DTLEDNREWY | QSRVPCSPPH | AIGPDRFKFE | LTLEETEEEE | EEDERH |