P26674

PR
Gene name
ste6 (SPCC1442.01, SPCC1450.17)
Protein name
Protein ste6
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1442.01
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

577-672 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26674

Entry ID Method Resolution Chain Position Source
AF-P26674-F1 Predicted AlphaFoldDB

No variants for P26674

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26674

No associated diseases with P26674

4 regional properties for P26674

Type Name Position InterPro Accession
domain Ras-like guanine nucleotide exchange factor, N-terminal 488 - 623 IPR000651
domain SH3 domain 1 - 60 IPR001452
domain Ras guanine-nucleotide exchange factors catalytic domain 659 - 895 IPR001895
conserved_site Ras guanine-nucleotide exchange factor, conserved site 811 - 852 IPR019804

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
actin fusion focus A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

4 GO annotations of biological process

Name Definition
conjugation with cellular fusion A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of pheromone response MAPK cascade Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRFQTTAISD YENSSNPSFL KFSAGDTIIV IEVLEDGWCD GICSEKRGWF PTSCIDSSKI
70 80 90 100 110 120
QNFFSSFHSS NEKDPNAQCC APFHVEAHLQ DSAWFEKHGV QAINSIPSSE EFLRKNLQND
130 140 150 160 170 180
IHHLVKGILT TAAAVSQSIK KEGTQVIVFG IETVRSMVLS FPLIILSTLD ENFLSEVAQV
190 200 210 220 230 240
FSSLNLLPEL SRMGCTYGEL CIRFTKLLKQ LANKFLFFFR PDVSFPSYFL GSLIAHEIHF
250 260 270 280 290 300
LPWDFNMLCS NSVQSAHTNL QPDITSFVAI LSLSHEAYHC TENEFWNLEA QKLTENTTQK
310 320 330 340 350 360
VLQLVAEDAL EAWKLDILED IDRCIQCCRR FLSANQRINY SSSENNPFSF TSQDVEALKD
370 380 390 400 410 420
ELSSNLCDLY LWSIDLEQIS PSDCLLDNYS LFVDLLVTLK VSLLRIKSII VQFSERIVFL
430 440 450 460 470 480
SLEYKFLTNI QPELNDAEKS QLDGFDLNKT NWFDSKGLVC YLMKQTSPEP LLIRNLLFSF
490 500 510 520 530 540
WSCNGKIEQD GKIKTATLVF IINYLLRTDI DSTFFTTIFL NTYASMISSS DLFSILGAHF
550 560 570 580 590 600
RFICSLNFGK ISFISHEFYR VSKRFLDILL IWFESYLVEE LDNSKSIFFL FKIYKVFEVF
610 620 630 640 650 660
VVPHFASAEE LLHSLSHLLH HPSTKRSHKM LEGKELSQEL EDLSLHNSPD PIIYKDELVL
670 680 690 700 710 720
LLPPREIAKQ LCILEFQSFS HISRIQFLTK IWDNLNRFSP KEKTSTFYLS NHLVNFVTET
730 740 750 760 770 780
IVQEEEPRRR TNVLAYFIQV CDYLRELNNF ASLFSIISAL NSSPIHRLRK TWANLNSKTL
790 800 810 820 830 840
ASFELLNNLT EARKNFSNYR DCLENCVLPC VPFLGVYFTD LTFLKTGNKD NFQNMINFDK
850 860 870 880 890 900
RTKVTRILNE IKKFQSVGYM FNPINEVQEL LNEVISRERN TNNIYQRSLT VEPRESEDQA
910
LQRLLIDSGI F