P26617

PR
Gene name
VEGFA (VEGF)
Protein name
Vascular endothelial growth factor A
Names
VEGF-A, Vascular permeability factor, VPF
Species
Cavia porcellus (Guinea pig)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

65-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26617

Entry ID Method Resolution Chain Position Source
AF-P26617-F1 Predicted AlphaFoldDB

No variants for P26617

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26617

No associated diseases with P26617

3 regional properties for P26617

Type Name Position InterPro Accession
domain PDGF/VEGF domain 12 - 108 IPR000072
conserved_site Platelet-derived growth factor, conserved site 48 - 60 IPR023581
domain Vascular endothelial growth factor, heparin-binding domain 112 - 164 IPR027928

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Secreted but remains associated to cells or to the extracellular matrix unless released by heparin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

11 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
motor neuron migration The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of endothelial cell migration Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation.
positive regulation of focal adhesion assembly Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly.
tube formation Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
APMAEGEQKP REEVKFMDVY KRSYCRPIEM LVDIFQEYPD EIEYIFKPSC VPLMRCGGCC
70 80 90 100 110 120
NDESLECVPT EEFNITMQIM RIKPHQGQHI GEMSFLQHSK CECRPKKEKA RQENPCGPCS
130 140 150 160
ERRKHLFVQD PQTCKCSCRN TDSRCKARQL ELNERTCRCD KPRR