P26363

PR
Gene name
cftr (abcc7)
Protein name
Cystic fibrosis transmembrane conductance regulator
Names
CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, cAMP-dependent chloride channel
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
5.6.1.6: Enzymes altering polypeptide conformation or assembly
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

358-440 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26363

Entry ID Method Resolution Chain Position Source
AF-P26363-F1 Predicted AlphaFoldDB

No variants for P26363

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26363

No associated diseases with P26363

9 regional properties for P26363

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 422 - 647 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1213 - 1446 IPR003439-2
domain AAA+ ATPase domain 451 - 815 IPR003593-1
domain AAA+ ATPase domain 1239 - 1421 IPR003593-2
domain ABC transporter type 1, transmembrane domain 83 - 351 IPR011527-1
domain ABC transporter type 1, transmembrane domain 866 - 1163 IPR011527-2
conserved_site ABC transporter-like, conserved site 549 - 563 IPR017871
domain CFTR regulator domain 640 - 851 IPR025837
domain Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 390 - 668 IPR047082

Functions

Description
EC Number 5.6.1.6 Enzymes altering polypeptide conformation or assembly
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Early endosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
chloride channel complex An ion channel complex through which chloride ions pass.
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

8 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
bicarbonate transmembrane transporter activity Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
chloride transmembrane transporter activity Enables the transfer of chloride ions from one side of a membrane to the other.
intracellularly ATP-gated chloride channel activity Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

9 GO annotations of biological process

Name Definition
bicarbonate transport The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
cellular response to forskolin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
chloride transmembrane transport The process in which chloride is transported across a membrane.
intracellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.
membrane hyperpolarization The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
multicellular organismal water homeostasis Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
transepithelial water transport The directed movement of water (H2O) from one side of an epithelium to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQKTPLEKAS IFSQIFFSWT KPILWKGYRQ RLELSDIYQI HPGDSADNLS ERLEREWDRE
70 80 90 100 110 120
VATSKKNPKL INALKRCFFW KFLFYGILLY LGEVTKAVQP LLLGRIIASY DRDNEHERSI
130 140 150 160 170 180
AYYLAIGLCL LFVVRMLLLH PAIFGLHHIG MQMRIAMFSL IYKKTLKLSS KVLDKISTGQ
190 200 210 220 230 240
LVSLLSNNLN KFDEGLALAH FVWIAPLQVL LLMGLLWDLL QASAFCGLGF LIILSLFQAR
250 260 270 280 290 300
LGRMMMKYKD KRAGKINERL VITSQIIENI QSVKAYCWEN AMEKIIETIR ETELKLTRKA
310 320 330 340 350 360
AYVRYFNSSA FFFSGFFVVF LSIVPHLLLD GISLRKIFTT ISFSIVLRMA VTRQFPWAVQ
370 380 390 400 410 420
TWYDSLGVIN KIQEFLQKEE YKSLEYNLTT TEVAMENVSA SWDEGIGEFF EKAKLEVNGG
430 440 450 460 470 480
NISNEDPSAF FSNFSLHVAP VLRNINFKIE KGQLLAIAGS TGAGKTSLLM MIMGELEPSA
490 500 510 520 530 540
GKIKHSGRIS FSPQVSWIMP GTIKENIVFG VSYDQYRYLS VIKACQLEED ISKFPEKDNT
550 560 570 580 590 600
VLGEGGITLS GGQRARISLA RAVYKDADLY LLDSPFSYLD LFTEKEIFES CVCKLMANKT
610 620 630 640 650 660
RILVTSKVEQ LKKADKVLIL HEGSCYFYGT FSELEDQRPE FSSHLIGFDH FNAERRNSII
670 680 690 700 710 720
TETLRRCSID SDPSAVRNEV KNKSFKQVAD FTEKRKSSII NPRKSSRKFS LMQKSQPQMS
730 740 750 760 770 780
GIEEEDMPAE QGERKLSLVP ESEQGEASLP RSNFLNTGPT FQGRRRQSVL NLMTRTSISQ
790 800 810 820 830 840
GSNAFATRNA SVRKMSVNSY SNSSFDLDIY NRRLSQDSIL EVSEEINEED LKECFLDDTD
850 860 870 880 890 900
SQSPTTTWNT YLRFLTAHKN FIFILVFCLV IFFVEVAASS AWLWIIKRNA PAINMTSNEN
910 920 930 940 950 960
VSEVSDTLSV IVTHTSFYYV FYIYVGVADS LLALGIFRGL PLVHSLISVS KVLHKKMLHA
970 980 990 1000 1010 1020
ILHAPMSTFN TMRAGRILNR FSKDTAILDD ILPLSIFDLT QLVLIVIGAI TVVSLLEPYI
1030 1040 1050 1060 1070 1080
FLATVPVIVA FILLRSYFLH TSQQLKQLES KARSPIFAHL ITSLKGLWTL RAFGRQPYFE
1090 1100 1110 1120 1130 1140
TLFHKALNLH TANWFLYLST LRWFQMTIEM IFVIFFIAVS FISIATSGAG EEKVGIVLTL
1150 1160 1170 1180 1190 1200
AMNIMNTLQW AVNASIDVDS LMRSVSRIFR FIDLPVEELI NENKNKEEQL SEVLIYENDY
1210 1220 1230 1240 1250 1260
VKKTQVWPSG GQMTVKNLSA NYIDGGNTVL ENISFSLSPG QRVGLLGRTG SGKSTLLSAF
1270 1280 1290 1300 1310 1320
LRLLSTQGDI QIDGVSWQTI PLQKWRKAFG VIPQKVFIFS GSIRKNLDPY GKWSDEELLK
1330 1340 1350 1360 1370 1380
VTEEVGLKLI IDQFPGQLDF VLLDGGCVLS HGHKQLVCLA RSVLSKAKIL LLDEPSAHLD
1390 1400 1410 1420 1430 1440
PITFQIIRKT LKHAFADCTV ILSEHRLEAM LECQRFLVIE DNTVRQYDSI QKLVNEKSFF
1450 1460 1470 1480
KQAISHSDRL KLFPLHRRNS SKRKSRPQIS ALQEETEEEV QDTRL