P26362

PR
Gene name
CFTR (ABCC7, DFTR)
Protein name
Cystic fibrosis transmembrane conductance regulator
Names
CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, Dogfish transmembrane conductance regulator, cAMP-dependent chloride channel
Species
Squalus acanthias (Spiny dogfish)
KEGG Pathway
EC number
5.6.1.6: Enzymes altering polypeptide conformation or assembly
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

618-878 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26362

Entry ID Method Resolution Chain Position Source
AF-P26362-F1 Predicted AlphaFoldDB

No variants for P26362

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26362

No associated diseases with P26362

8 regional properties for P26362

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 424 - 647 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1220 - 1453 IPR003439-2
domain AAA+ ATPase domain 451 - 808 IPR003593-1
domain AAA+ ATPase domain 1246 - 1429 IPR003593-2
domain ABC transporter type 1, transmembrane domain 83 - 350 IPR011527-1
domain ABC transporter type 1, transmembrane domain 869 - 1169 IPR011527-2
conserved_site ABC transporter-like, conserved site 549 - 563 IPR017871
domain CFTR regulator domain 640 - 858 IPR025837

Functions

Description
EC Number 5.6.1.6 Enzymes altering polypeptide conformation or assembly
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Early endosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
chloride channel complex An ion channel complex through which chloride ions pass.
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

8 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
bicarbonate transmembrane transporter activity Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
chloride transmembrane transporter activity Enables the transfer of chloride ions from one side of a membrane to the other.
intracellularly ATP-gated chloride channel activity Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

9 GO annotations of biological process

Name Definition
bicarbonate transport The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
cellular response to forskolin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
chloride transmembrane transport The process in which chloride is transported across a membrane.
intracellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.
membrane hyperpolarization The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
multicellular organismal water homeostasis Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
transepithelial water transport The directed movement of water (H2O) from one side of an epithelium to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRSPIEKAN AFSKLFFRWP RPILKKGYRQ KLELSDIYQI PSSDSADELS EMLEREWDRE
70 80 90 100 110 120
LATSKKNPKL VNALRRCFFW RFLFYGILLY FVEFTKAVQP LCLGRIIASY NAKNTYEREI
130 140 150 160 170 180
AYYLALGLCL LFVVRTLFLH PAVFGLQHLG MQMRIALFSL IYKKILKMSS RVLDKIDTGQ
190 200 210 220 230 240
LVSLLSNNLN KFDEGVAVAH FVWIAPVQVV LLMGLIWNEL TEFVFCGLGF LIMLALFQAW
250 260 270 280 290 300
LGKKMMQYRD KRAGKINERL AITSEIIDNI QSVKVYCWED AMEKIIDDIR QVELKLTRKV
310 320 330 340 350 360
AYCRYFSSSA FFFSGFFVVF LSVVPYAFIH TIKLRRIFTT ISYNIVLRMT VTRQFPSAIQ
370 380 390 400 410 420
TWYDSLGAIR KIQDFLHKDE HKTVEYNLTT KEVEMVNVTA SWDEGIGELF EKVKQNDSER
430 440 450 460 470 480
KMANGDDGLF FSNFSLHVTP VLKNISFKLE KGELLAIAGS TGSGKSSLLM MIMGELEPSD
490 500 510 520 530 540
GKIKHSGRIS YSPQVPWIMP GTIKDNIIFG LSYDEYRYTS VVNACQLEED ITVFPNKDKT
550 560 570 580 590 600
VLGDGGITLS GGQRARISLA RALYKDADLY LLDSPFSHLD VTTEKDIFES CLCKLMVNKT
610 620 630 640 650 660
RILVTSKLEH LKKADKILLL HEGHCYFYGT FSELQGEKPD FSSQLLGSVH FDSFSAERRN
670 680 690 700 710 720
SILTETFRRC SVSSGDGAGL GSYSETRKAS FKQPPPEFNE KRKSSLIVNP ITSNKKFSLV
730 740 750 760 770 780
QTAMSYPQTN GMEDATSEPG ERHFSLIPEN ELGEPTKPRS NIFKSELPFQ AHRRQSVLAL
790 800 810 820 830 840
MTHSSTSPNK IHARRSAVRK MSMLSQTNFA SSEIDIYSRR LSEDGSFEIS EEINEEDLKE
850 860 870 880 890 900
CFADEEEIQN VTTTWSTYLR YVTTNRNLVF VLILCLVIFL AEVAASLAGL WIISGLAINT
910 920 930 940 950 960
GSQTNDTSTD LSHLSVFSKF ITNGSHYYIF YIYVGLADSF LALGVIRGLP LVHTLVTVSK
970 980 990 1000 1010 1020
DLHKQMLHSV LQGPMTAFNK MKAGRILNRF IKDTAIIDDM LPLTVFDFVQ LILIVVGAIC
1030 1040 1050 1060 1070 1080
VVSVLQPYTL LAAIPVAVIF IMLRAYFLRT SQQLKQLESE ARSPIFSHLI TSLRGLWTVR
1090 1100 1110 1120 1130 1140
AFGRQSYFET LFHKALNLHT ANWFLYLSTL RWFQMRIDIV FVLFFIAVTF IAIATHDVGE
1150 1160 1170 1180 1190 1200
GQVGIILTLA MNITSTLQWA VNSSIDVDGL MRSVSRVFKY IDIPPEGSET KNRHNANNPS
1210 1220 1230 1240 1250 1260
DVLVIENKHL TKEWPSGGQM MVNNLTAKYT SDGRAVLQDL SFSVNAGQRV GLLGRTGAGK
1270 1280 1290 1300 1310 1320
STLLSALLRL LSTEGEIQID GISWNSVSLQ KWRKAFGVIP QKVFVFSGTF RKNLDPYEQW
1330 1340 1350 1360 1370 1380
SDEEIWKVTE EVGLKSMIEQ FPDKLNFVLV DGGYILSNGH KQLMCLARSI LSKAKILLLD
1390 1400 1410 1420 1430 1440
EPTAHLDPVT FQIIRKTLKH TFSNCTVILS EHRVEALLEC QQFLVIEGCS VKQFDALQKL
1450 1460 1470 1480 1490
LTEASLFKQV FGHLDRAKLF TAHRRNSSKR KTRPKISALQ EEAEEDLQET RL