P26329

PR
Gene name
Protein name
Variant surface glycoprotein ILTAT 1.24
Names
VSG
Species
Trypanosoma brucei brucei
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

212-350 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P26329

Entry ID Method Resolution Chain Position Source
2JWG NMR - A 405-450 PDB
2JWH NMR - A 445-491 PDB
2VSG X-ray 270 A A/B 24-381 PDB
AF-P26329-F1 Predicted AlphaFoldDB

No variants for P26329

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26329

No associated diseases with P26329

2 regional properties for P26329

Type Name Position InterPro Accession
domain Trypanosome variant surface glycoprotein, A-type, N-terminal domain 21 - 378 IPR001812
domain Trypanosome variant surface glycoprotein, C-terminal 412 - 513 IPR019609

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Lipid-anchor, GPI-anchor
  • A soluble form is released from ruptured cells by the action of a PI-PLC
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
anchored component of membrane The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
evasion of host immune response A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVYRNILQLS VLKVLLIVLI VEATHFGVKY ELWQPECELT AELRKTAGVA KMKVNSDLNS
70 80 90 100 110 120
FKTLELTKMK LLTFAAKFPE SKEALTLRAL EAALNTDLRA LRDNIANGID RAVRATAYAS
130 140 150 160 170 180
EAAGALFSGI QTLHDATDGT TYCLSASGQG SNGNAAMASQ GCKPLALPEL LTEDSYNTDV
190 200 210 220 230 240
ISDKGFPKIS PLTNAQGQGK SGECGLFQAA SGAQATNTGV QFSGGSRINL GLGAIVASAA
250 260 270 280 290 300
QQPTRPDLSD FSGTARNQAD TLYGKAHASI TELLQLAQGP KPGQTEVETM KLLAQKTAAL
310 320 330 340 350 360
DSIKFQLAAS TGKKTSDYKE DENLKTEYFG KTESNIEALW NKVKEEKVKG ADPEDPSKES
370 380 390 400 410 420
KISDLNTEEQ LQRVLDYYAV ATMLKLAKQA EDIAKLETEI ADQRGKSPEA ECNKITEEPK
430 440 450 460 470 480
CSEEKICSWH KEVKAGEKNC QFNSTKASKS GVPVTQTQTA GADTTAEKCK GKGEKDCKSP
490 500 510
DCKWEGGTCK DSSILANKQF ALSVASAAFV ALLF