P26281

PR
Gene name
folK (b0142, JW0138)
Protein name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Names
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0142
EC number
2.7.6.3: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

59 structures for P26281

Entry ID Method Resolution Chain Position Source
1DY3 X-ray 200 A A 2-159 PDB
1EQ0 NMR - A 2-159 PDB
1EQM X-ray 150 A A 2-159 PDB
1EX8 X-ray 185 A A 2-159 PDB
1F9H X-ray 150 A A 2-159 PDB
1G4C X-ray 165 A A/B 2-159 PDB
1HKA X-ray 150 A A 2-159 PDB
1HQ2 X-ray 125 A A 2-159 PDB
1IM6 X-ray 174 A A 2-159 PDB
1KBR X-ray 155 A A 2-159 PDB
1Q0N X-ray 125 A A 2-159 PDB
1RAO X-ray 156 A A 2-159 PDB
1RB0 X-ray 135 A A 2-159 PDB
1RTZ X-ray 133 A A 2-159 PDB
1RU1 X-ray 140 A A/B 2-159 PDB
1RU2 X-ray 148 A A 2-159 PDB
1TMJ X-ray 145 A A 2-159 PDB
1TMM X-ray 125 A A/B 2-159 PDB
2F63 NMR - A 2-159 PDB
2F65 NMR - A 2-159 PDB
3HCX X-ray 175 A A 2-159 PDB
3HD1 X-ray 130 A A 2-159 PDB
3HD2 X-ray 110 A A 2-159 PDB
3HSD X-ray 165 A A/B 2-159 PDB
3HSG X-ray 114 A A 2-159 PDB
3HSJ X-ray 118 A A 2-159 PDB
3HSZ X-ray 140 A A 2-159 PDB
3HT0 X-ray 140 A A 2-159 PDB
3ILI X-ray 145 A A 2-159 PDB
3ILJ X-ray 165 A A 2-159 PDB
3ILL X-ray 173 A A 2-159 PDB
3ILO X-ray 110 A A 2-159 PDB
3IP0 X-ray 089 A A 2-159 PDB
3KUE X-ray 154 A A 2-159 PDB
3KUG X-ray 200 A A 2-159 PDB
3KUH X-ray 135 A A 2-159 PDB
3UD5 X-ray 200 A A 2-159 PDB
3UDE X-ray 188 A A 2-159 PDB
3UDV X-ray 188 A A 2-159 PDB
4F7V X-ray 173 A A 2-159 PDB
4M5G X-ray 131 A A 1-159 PDB
4M5H X-ray 111 A A 1-159 PDB
4M5I X-ray 108 A A 1-159 PDB
4M5J X-ray 170 A A 1-159 PDB
4M5K X-ray 130 A A 1-159 PDB
4M5L X-ray 109 A A 1-159 PDB
4M5M X-ray 112 A A 1-159 PDB
4M5N X-ray 200 A A/B 1-159 PDB
5ETK X-ray 109 A A 1-159 PDB
5ETL X-ray 182 A A/B/C/D 1-159 PDB
5ETM X-ray 146 A A 1-159 PDB
5ETN X-ray 140 A A 1-159 PDB
5ETO X-ray 107 A A 1-159 PDB
5ETP X-ray 105 A A 1-159 PDB
6AN4 X-ray 147 A A 2-159 PDB
6AN6 X-ray 230 A A/B 2-159 PDB
7KDO X-ray 160 A A 2-159 PDB
7KDR X-ray 149 A A 2-159 PDB
AF-P26281-F1 Predicted AlphaFoldDB

No variants for P26281

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26281

No associated diseases with P26281

1 regional properties for P26281

Type Name Position InterPro Accession
domain 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK 4 - 134 IPR000550

Functions

Description
EC Number 2.7.6.3 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
magnesium ion binding Binding to a magnesium (Mg) ion.

3 GO annotations of biological process

Name Definition
folic acid biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVAYIAIGS NLASPLEQVN AALKALGDIP ESHILTVSSF YRTPPLGPQD QPDYLNAAVA
70 80 90 100 110 120
LETSLAPEEL LNHTQRIELQ QGRVRKAERW GPRTLDLDIM LFGNEVINTE RLTVPHYDMK
130 140 150
NRGFMLWPLF EIAPELVFPD GEMLRQILHT RAFDKLNKW