P26144

PR
Gene name
PB1
Protein name
RNA-directed RNA polymerase catalytic subunit
Names
Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1
Species
Influenza A virus (strain A/Camel/Mongolia/1982 H1N1)
KEGG Pathway
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

40-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26144

Entry ID Method Resolution Chain Position Source
1WBZ X-ray 200 A P/Q 107-115 PDB

No variants for P26144

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P26144

No associated diseases with P26144

No regional properties for P26144

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P26144

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
  • Host nucleus
  • Host cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

3 GO annotations of molecular function

Name Definition
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host mRNA transcription by directly inhibiting RNA polymerase II activity.
viral RNA genome replication The replication of a viral RNA genome.
viral transcription The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
NLYNIRNLHI PEVCLKWELM DEDYQGRLCN PLNPFVSHKE IESVNNAVMM PAHGPAKNME
70 80 90 100 110 120
YDAVATTHSW VPKRNRSILN TSQRGILEDE QMYQRCCNLF EKFFPSSSYR RPVGISSMVE
130 140 150 160
AMVSRARIDA RIDFESGRIK KEEFTEIMKT CSTIEELRRQ K