AiPD: Autoinhibited Protein Database

P25685

Gene name	DNAJB1 (DNAJ1, HDJ1, HSPF1)
Protein name	DnaJ homolog subfamily B member 1
Names	DnaJ protein homolog 1, Heat shock 40 kDa protein 1, HSP40, Heat shock protein 40, Human DnaJ protein 1, hDj-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3337
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-224 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

116-224 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

15 structures for P25685

Entry ID	Method	Resolution	Chain	Position	Source
1HDJ	NMR	-	A	1-76	PDB
2QLD	X-ray	270 A	A	158-340	PDB
3AGX	X-ray	185 A	A/B	161-340	PDB
3AGY	X-ray	185 A	A/B	161-340	PDB
3AGZ	X-ray	251 A	A/B	151-340	PDB
4WB7	X-ray	190 A	A/B	2-70	PDB
6BYR	X-ray	366 A	A/C	2-70	PDB
6WJF	EM	750 A	A/B	2-70	PDB
6WJG	EM	620 A	A/B	2-70	PDB
6Z5N	NMR	-	A	1-110	PDB
7NDX	X-ray	254 A	A	157-340	PDB
8FE2	X-ray	234 A	A/B	2-70	PDB
8FE5	X-ray	251 A	A/B	2-70	PDB
8FEC	X-ray	270 A	A/B	2-70	PDB
AF-P25685-F1	Predicted				AlphaFoldDB

327 variants for P25685

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1472513774 CA404447718	3	K>E		No	ClinGen gnomAD
rs1367177388 CA404447714	3	K>R		No	ClinGen gnomAD
CA305693094 rs891936896	4	D>N		No	ClinGen TOPMed
CA404447673 rs1207240675	6	Y>H		No	ClinGen TOPMed gnomAD
rs779624471 CA9254790	7	Q>H		No	ClinGen ExAC gnomAD
CA305693069 rs11540700	8	T>M		No	ClinGen TOPMed gnomAD
CA305693077 rs11540700	8	T>R		No	ClinGen TOPMed gnomAD
TCGA novel	9	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305693051 rs778361162	9	L>V		No	ClinGen TOPMed
rs368275838 CA9254787	10	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1341043222 CA404447615	10	G>D		No	ClinGen gnomAD
CA9254783 rs201552567	11	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9254784 rs201552567	11	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1321486517 CA404447593	12	A>G		No	ClinGen gnomAD
CA9254782 rs753791685	12	A>P		No	ClinGen ExAC gnomAD
rs1321486517 CA404447591	12	A>V		No	ClinGen gnomAD
rs766545114 CA9254781	13	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1458818816 CA404447571	14	G>D		No	ClinGen TOPMed gnomAD
rs761547055 CA9254777	15	A>S		No	ClinGen ExAC gnomAD
CA9254778 rs761547055	15	A>T		No	ClinGen ExAC gnomAD
CA404447541 rs1413942520	16	S>L		No	ClinGen TOPMed
CA404447525 rs774213662	17	D>E		No	ClinGen ExAC TOPMed gnomAD
rs768130288 CA404447516	18	E>*		No	ClinGen ExAC gnomAD
rs768130288 COSM460049 CA9254775	18	E>K	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1287106631 CA404447486	19	E>D		No	ClinGen gnomAD
CA404447502 rs1450723645	19	E>K		No	ClinGen gnomAD
CA404447455 rs1382310400	21	K>N		No	ClinGen TOPMed
rs749040460 CA404447433	23	A>S		No	ClinGen ExAC TOPMed gnomAD
rs749040460 CA9254774	23	A>T		No	ClinGen ExAC TOPMed gnomAD
CA404447409 rs774852640	24	Y>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel rs373251842 CA305692985	24	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA404447402 rs1225832152	25	R>C		No	ClinGen TOPMed gnomAD
CA404447389 rs1367080747	26	R>C		No	ClinGen gnomAD
CA9254771 rs747484683	26	R>H		No	ClinGen ExAC TOPMed gnomAD
CA9254772 rs747484683	26	R>L		No	ClinGen ExAC TOPMed gnomAD
CA404447333 rs1329583135	30	R>G		No	ClinGen gnomAD
rs758991587 CA9254769	30	R>H		No	ClinGen ExAC gnomAD
rs748402159 CA9254768	31	Y>C		No	ClinGen ExAC gnomAD
rs1002030787 CA305692939	33	P>L		No	ClinGen TOPMed
CA404447235 rs1348811211	35	K>N		No	ClinGen TOPMed
CA404447179 rs1172409599	38	E>D		No	ClinGen gnomAD
rs1477463475 CA404447177	39	P>A		No	ClinGen gnomAD
rs201570588 CA9254764	39	P>L		No	ClinGen 1000Genomes ExAC
rs370382932 CA9254762	40	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA305692919 rs555433458	40	G>C		No	ClinGen 1000Genomes gnomAD
CA9254759 rs774015686	42	E>A		No	ClinGen ExAC gnomAD
CA404447136 rs1490195444	42	E>K		No	ClinGen TOPMed
CA9254757 rs762488215	43	E>G		No	ClinGen ExAC gnomAD
CA9254758 rs764010316	43	E>K		No	ClinGen ExAC TOPMed gnomAD
CA404447099 rs1349942081	46	K>E		No	ClinGen gnomAD
CA404447096 rs1306302394	46	K>R		No	ClinGen gnomAD
CA9254752 rs367975514	47	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA404447085 rs369777056	48	I>L		No	ClinGen TOPMed
rs748754745 CA404447081	48	I>M		No	ClinGen ExAC TOPMed gnomAD
CA9254750 rs199815171	48	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1611673 CA305692838 rs369777056	48	I>V	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1172513421 CA404447076	49	A>G		No	ClinGen TOPMed gnomAD
CA404447080 rs1422551441 COSM709780	49	A>S	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs773831291 CA9254745	52	Y>*		No	ClinGen ExAC
rs756342083 CA404447038	55	L>F		No	ClinGen ExAC TOPMed gnomAD
rs756342083 CA9254743	55	L>V		No	ClinGen ExAC TOPMed gnomAD
CA404447032 rs1483970108	56	S>G		No	ClinGen gnomAD
rs1233386964 CA404447030	56	S>N		No	ClinGen gnomAD
rs757131921 CA9254740	59	R>C		No	ClinGen ExAC TOPMed gnomAD
rs558398911 CA9254739	59	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1284141662 CA404446987	62	E>D		No	ClinGen TOPMed gnomAD
CA9254738 rs763763598	62	E>V		No	ClinGen ExAC gnomAD
rs1335325642 CA404446961	66	R>C		No	ClinGen gnomAD
rs141580276 CA9254732	67	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs759266426 CA9254734	67	Y>D		No	ClinGen ExAC gnomAD
rs1370569162 CA404446949	68	G>W		No	ClinGen TOPMed
rs376653817 CA9254689	73	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1263079262 CA404446480	74	G>A		No	ClinGen TOPMed
rs1355201022 CA404446475	75	S>N		No	ClinGen TOPMed
rs766997470 CA9254686	76	G>S		No	ClinGen ExAC gnomAD
TCGA novel	77	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1261966987 CA404446459	78	S>G		No	ClinGen TOPMed
rs1300191782 CA404446454	78	S>I		No	ClinGen gnomAD
TCGA novel	80	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346811072 CA404446444	80	G>R		No	ClinGen gnomAD
rs763431752 CA9254685	81	S>T		No	ClinGen ExAC TOPMed gnomAD
CA9254684 rs528346099	82	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404446425 rs1599380163	83	G>C		No	ClinGen Ensembl
rs1159723995 CA404446415	85	A>T		No	ClinGen TOPMed
CA9254682 rs759842362	86	N>D		No	ClinGen ExAC TOPMed gnomAD
rs369749322 CA9254681	86	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs376056897 CA9254680	87	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1599380145 CA404446398	88	T>A		No	ClinGen Ensembl
rs747261359 CA9254679	88	T>I		No	ClinGen ExAC TOPMed gnomAD
CA404446388 rs1254636737	89	S>F		No	ClinGen gnomAD
CA305691772 rs768632960	90	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1392387346 CA404446379	91	S>G		No	ClinGen TOPMed
rs1483115469 CA404446375	91	S>N		No	ClinGen gnomAD
CA404446365 rs1254667428	92	Y>*		No	ClinGen gnomAD
CA404446363 rs1207579075 COSM3742777	93	T>A	liver [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA404446359 rs1352192209	93	T>I		No	ClinGen TOPMed
rs778946514 CA9254675	95	H>R		No	ClinGen ExAC TOPMed gnomAD
CA404446327 rs1359624363	98	P>S		No	ClinGen TOPMed
rs370822819 CA9254671	99	H>L		No	ClinGen ESP ExAC gnomAD
rs370822819 CA9254670	99	H>R		No	ClinGen ESP ExAC gnomAD
CA9254672 rs779780963	99	H>Y		No	ClinGen ExAC gnomAD
rs373025639 CA9254667	101	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs756719881 CA9254668	101	M>V		No	ClinGen ExAC TOPMed gnomAD
CA404446287 rs1471664346	104	E>A		No	ClinGen gnomAD
CA404446265 rs1423811338	107	G>C		No	ClinGen gnomAD
CA305691734 rs868529739	108	G>S		No	ClinGen TOPMed
CA404446246 rs1568380218	110	N>S		No	ClinGen Ensembl
CA9254662 rs760929049	111	P>S		No	ClinGen ExAC gnomAD
CA404446236 rs1263403047	112	F>I		No	ClinGen gnomAD
rs1207492505 CA404446221	113	D>E		No	ClinGen gnomAD
CA9254659 rs761928598	116	F>S		No	ClinGen ExAC gnomAD
rs1162923772 CA404446199	117	G>R		No	ClinGen TOPMed
rs1239666815	117	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA9254658 rs140996277	119	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1298506333 CA404446184	119	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA305691684 rs376854236	120	N>K		No	ClinGen ESP TOPMed gnomAD
rs749246039 CA9254656	121	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1042130283 CA305691672	121	G>R		No	ClinGen TOPMed
rs769519959 CA9254654	127	I>M		No	ClinGen ExAC TOPMed gnomAD
CA9254655 rs779880650	127	I>V		No	ClinGen ExAC TOPMed gnomAD
rs751000296 CA9254650	130	P>L		No	ClinGen ExAC gnomAD
rs756913687 CA9254651	130	P>S		No	ClinGen ExAC gnomAD
rs575725653 CA305691642	131	F>C		No	ClinGen 1000Genomes
COSM991916 rs532172007 CA9254649	131	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs754350664 CA9254647	132	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1197923450 CA404446079	133	G>C		No	ClinGen TOPMed
rs760907452 CA9254645	135	P>L		No	ClinGen ExAC gnomAD
CA9254646 rs766733011	135	P>S		No	ClinGen ExAC TOPMed gnomAD
rs753013282 CA9254644	136	M>V	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767783285 CA9254643	137	G>D		No	ClinGen ExAC
TCGA novel	137	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1413284083 CA404446018	138	M>L		No	ClinGen TOPMed
rs1413284083 CA404446016	138	M>V		No	ClinGen TOPMed
rs774560970 CA9254641	139	G>V		No	ClinGen ExAC gnomAD
rs762921008 CA404445986	140	G>D		No	ClinGen ExAC gnomAD
CA9254640 rs768909513	140	G>S		No	ClinGen ExAC gnomAD
CA9254639 rs762921008	140	G>V		No	ClinGen ExAC gnomAD
rs1359847893 CA404445973	141	F>C		No	ClinGen gnomAD
rs769796405 CA9254637	143	N>S		No	ClinGen ExAC gnomAD
CA404445931 rs1398551866	144	V>G		No	ClinGen TOPMed
rs745589757 CA9254636	144	V>M		No	ClinGen ExAC TOPMed gnomAD
CA404445916 rs780967565	145	N>K		No	ClinGen ExAC gnomAD
rs1318982440 CA404445903	146	F>C		No	ClinGen gnomAD
CA305691585 rs151186891	147	G>D		No	ClinGen ESP TOPMed gnomAD
rs151186891 CA404445890	147	G>V		No	ClinGen ESP TOPMed gnomAD
rs200218269 CA9254633	148	R>L		No	ClinGen 1000Genomes ExAC
CA305691566 rs201408385	150	R>C		No	ClinGen TOPMed gnomAD
CA305691568 rs201408385	150	R>G		No	ClinGen TOPMed gnomAD
CA9254632 rs142178968	150	R>L		No	ClinGen ESP ExAC TOPMed
CA9254631 rs574927325	151	S>C		No	ClinGen 1000Genomes ExAC gnomAD
CA404445850 rs574927325	151	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA9254629 rs780375642	153	Q>R		No	ClinGen ExAC gnomAD
CA404445789 rs750748627	156	A>S		No	ClinGen ExAC TOPMed gnomAD
CA9254627 rs750748627	156	A>T		No	ClinGen ExAC TOPMed gnomAD
CA404445784 rs1266201789	156	A>V		No	ClinGen gnomAD
rs373095952 CA9254625	158	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA305691529 rs955434760	159	K>Q		No	ClinGen TOPMed
TCGA novel	161	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764446419 CA9254623	162	P>S		No	ClinGen ExAC gnomAD
rs775649881 CA9254621	163	P>A		No	ClinGen ExAC TOPMed gnomAD
CA404445718 rs1329417226	163	P>L		No	ClinGen TOPMed gnomAD
CA404445721 rs775649881	163	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9254619 rs553112983	165	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA404445700 COSM1523798 rs776395351	166	H>Q	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA404445702 rs1412022074	166	H>R		No	ClinGen gnomAD
CA9254615 rs368973570	167	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA9254617 rs770760423	167	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9254614 rs771777358	168	L>F		No	ClinGen ExAC gnomAD
rs778551714 CA9254612	173	E>*		No	ClinGen ExAC gnomAD
rs1202117106 CA404445651	174	E>D		No	ClinGen gnomAD
CA9254611 rs756568093	175	I>F		No	ClinGen ExAC gnomAD
CA404445614 rs1224241023	179	C>W		No	ClinGen gnomAD
rs757193946	182	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1599379666 CA404445570	185	I>T		No	ClinGen Ensembl
rs1286980191 CA404445573	185	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9254606 rs751998524	186	S>C		No	ClinGen ExAC TOPMed gnomAD
rs751998524 CA404445563	186	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	187	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758647493 CA9254604	187	H>Y		No	ClinGen ExAC gnomAD
CA305691454 rs1017362665	189	R>Q		No	ClinGen TOPMed gnomAD
rs376959865 CA9254601	190	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9254599 rs534990611	191	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs760412625 CA9254598	192	P>A		No	ClinGen ExAC gnomAD
CA305691425 rs868417170	192	P>L		No	ClinGen Ensembl
rs771619426 CA9254597	193	D>H		No	ClinGen ExAC gnomAD
rs771619426 CA9254596	193	D>N		No	ClinGen ExAC gnomAD
rs773713356 CA9254594	196	S>N		No	ClinGen ExAC gnomAD
rs1275237222 CA404445498	197	I>T		No	ClinGen TOPMed
rs748841793 CA9254592	198	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA404445485 rs1328538533	199	N>I		No	ClinGen gnomAD
rs202063146 CA9254588	201	D>H		No	ClinGen ExAC gnomAD
CA9254587 rs202063146	201	D>N		No	ClinGen ExAC gnomAD
CA9254589 rs202063146	201	D>Y		No	ClinGen ExAC gnomAD
CA9254586 rs753009308	203	I>L		No	ClinGen ExAC TOPMed gnomAD
rs1367344143 CA404445456	203	I>M		No	ClinGen gnomAD
rs753009308 CA404445461	203	I>V		No	ClinGen ExAC TOPMed gnomAD
CA9254582 rs766245306	207	E>K		No	ClinGen ExAC gnomAD
CA404445419 rs1156338465	209	K>T		No	ClinGen gnomAD
rs1372071235 CA404445410	210	K>R		No	ClinGen gnomAD
CA404445403 rs1218935394	211	G>E		No	ClinGen TOPMed
TCGA novel	214	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404445333 rs1248818343	221	P>A		No	ClinGen TOPMed
TCGA novel	221	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9254576 rs768218111	222	K>E		No	ClinGen ExAC gnomAD
CA404445313 rs1464662129	224	G>R		No	ClinGen gnomAD
rs1172485177 CA404445303	225	D>A		No	ClinGen TOPMed
rs775147909 CA9254574 COSM3937896	225	D>E	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs771556939 CA9254573	226	Q>E		No	ClinGen ExAC gnomAD
rs144442851 CA9254572	227	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1599379418 CA404445293	227	T>P		No	ClinGen Ensembl
rs772524581 CA9254570	229	N>K		No	ClinGen ExAC gnomAD
CA305691311 rs761197816	231	I>M		No	ClinGen gnomAD
CA9254568 rs369699868	231	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1360848056 CA404445261	232	P>A		No	ClinGen gnomAD
rs1178145050 CA404445239	235	I>T		No	ClinGen TOPMed gnomAD
CA9254567 rs755205651	235	I>V		No	ClinGen ExAC TOPMed gnomAD
rs367631765 CA305691303	236	V>I		No	ClinGen ESP TOPMed
TCGA novel	238	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404445223 rs1433767205	238	V>I		No	ClinGen TOPMed gnomAD
CA305691279 rs113305966	244	H>L		No	ClinGen Ensembl
CA305691287 rs113305966	244	H>R		No	ClinGen Ensembl
CA305691273 rs946484777	245	N>D		No	ClinGen TOPMed
rs150659482 CA9254562	245	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1292355169 CA404445160	247	F>L		No	ClinGen TOPMed
CA404445153 rs1599379274	248	K>Q		No	ClinGen Ensembl
CA404445133 rs1188306980	250	D>G		No	ClinGen gnomAD
rs1417674736 CA404445138	250	D>N		No	ClinGen gnomAD
rs1417674736 CA404445136	250	D>Y		No	ClinGen gnomAD
CA404445128 rs1486220362	251	G>S		No	ClinGen gnomAD
CA9254557 rs775122962	252	S>F		No	ClinGen ExAC gnomAD
TCGA novel	253	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773728006 CA9254554	256	Y>F		No	ClinGen ExAC gnomAD
rs539047458 CA9254553	257	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs568962152 CA305691239	258	A>T		No	ClinGen 1000Genomes gnomAD
rs1211427373 CA404445082	258	A>V		No	ClinGen gnomAD
CA9254552 rs748486862	259	R>G		No	ClinGen ExAC gnomAD
rs779148550 CA404445076 CA9254551	259	R>S		No	ClinGen ExAC gnomAD
rs768852879 CA9254550	261	S>G		No	ClinGen ExAC TOPMed gnomAD
rs749561047 CA9254549	262	L>F		No	ClinGen ExAC gnomAD
rs756147811 CA9254547	263	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs765857048 CA9254514	265	A>V		No	ClinGen ExAC gnomAD
rs144022754 CA9254513	266	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404444882 rs1437965400	269	C>Y		No	ClinGen TOPMed
CA305690860 rs890088956	272	N>T		No	ClinGen TOPMed
CA9254511 rs764609404	273	V>A		No	ClinGen ExAC gnomAD
CA404444833 rs1158083531	273	V>I		No	ClinGen gnomAD
rs763247276 CA9254510	274	P>S		No	ClinGen ExAC gnomAD
rs746137932 CA9254507	276	L>V		No	ClinGen ExAC TOPMed gnomAD
CA9254505 rs770952866	277	D>A		No	ClinGen ExAC gnomAD
CA9254503 rs777801014	278	G>S		No	ClinGen ExAC TOPMed gnomAD
rs758421270 CA9254502	280	T>A		No	ClinGen ExAC TOPMed gnomAD
COSM991911 rs552175454 CA9254501	280	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA404444744 rs1312725509	281	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA404444747 rs1358463898	281	I>V		No	ClinGen gnomAD
rs1248373954 CA404444741	282	P>A		No	ClinGen gnomAD
rs1248373954 CA404444740	282	P>S		No	ClinGen gnomAD
CA9254498 rs370485830	283	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs374296355 CA9254496	284	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA9254495 rs374296355	284	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA305690761 rs941823539	285	F>L		No	ClinGen TOPMed
CA9254494 rs764521482	287	D>N		No	ClinGen ExAC gnomAD
rs765566260 CA404444693	289	I>M		No	ClinGen ExAC TOPMed gnomAD
CA9254492 rs753050653	289	I>T		No	ClinGen ExAC gnomAD
CA9254490 rs759769250	290	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1368711011 CA404444687	290	R>S		No	ClinGen gnomAD
CA404444690 rs759769250	290	R>T		No	ClinGen ExAC TOPMed gnomAD
CA305690676 rs938141167	291	P>R		No	ClinGen TOPMed
rs776673751 CA9254489	291	P>T		No	ClinGen ExAC TOPMed gnomAD
CA404444680 rs1263313620	292	G>C		No	ClinGen gnomAD
CA9254487 rs760777348	292	G>D		No	ClinGen ExAC TOPMed
CA9254485 rs772131060	294	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9254486 rs143320658 COSM330692	294	R>W	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs748154927 CA404444664	295	R>G		No	ClinGen ExAC TOPMed gnomAD
rs778737677 CA9254483	295	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA404444647 rs1269803421	298	P>A		No	ClinGen gnomAD
rs148288780 CA404444644	298	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9254482 rs148288780	298	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA404444614 rs1333849588	303	P>S		No	ClinGen TOPMed
CA404444608 rs1404811853	304	L>F		No	ClinGen gnomAD
CA404444600 rs1259860352	305	P>L		No	ClinGen TOPMed
CA9254480 rs370674842	305	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1326696282 CA404444595	306	K>R		No	ClinGen gnomAD
rs1436026537 CA404444582	308	P>H		No	ClinGen TOPMed
CA9254478 rs749934387	309	E>K		No	ClinGen ExAC TOPMed gnomAD
CA404444579 rs749934387	309	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs780742552 CA9254477	310	K>E		No	ClinGen ExAC gnomAD
rs758885471 CA9254476	311	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9254475 rs377564300	311	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9254474 rs377564300	311	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9254472 rs143246504	313	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA404444553 rs1480047284	313	D>V		No	ClinGen gnomAD
CA9254471 rs766443671	314	L>V		No	ClinGen ExAC TOPMed gnomAD
CA404444529 rs1437276279	317	E>Q		No	ClinGen gnomAD
rs773412227 CA9254469	318	F>L		No	ClinGen ExAC gnomAD
CA404444520 rs1568379091	318	F>S		No	ClinGen Ensembl
TCGA novel	319	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404444514 rs1272110558	319	E>Q		No	ClinGen gnomAD
rs1177508105 CA404444507	320	V>L		No	ClinGen TOPMed
CA9254468 rs199744224	321	I>S		No	ClinGen ExAC gnomAD
CA9254464 rs748971999	323	P>L		No	ClinGen ExAC gnomAD
rs1400322538 CA404444479	324	E>G		No	ClinGen TOPMed
rs377706903 CA9254462	324	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404444475 rs1406169543	325	R>G		No	ClinGen TOPMed gnomAD
CA9254461 rs745573140	326	I>M		No	ClinGen ExAC gnomAD
rs780644757 CA9254460	327	P>R		No	ClinGen ExAC gnomAD
rs1327285879 CA404444460	327	P>S		No	ClinGen gnomAD
TCGA novel	328	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305690468 rs561895564	328	Q>R		No	ClinGen Ensembl
rs532564939 CA9254457	329	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs138234955 CA9254456	330	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1201495369 CA404444428	332	T>I		No	ClinGen gnomAD
CA404444430 rs1201495369	332	T>N		No	ClinGen gnomAD
rs750634405 CA9254451	333	V>A		No	ClinGen ExAC gnomAD
CA9254452 rs756381480	333	V>I		No	ClinGen ExAC gnomAD
rs1439733347 CA404444421	334	L>F		No	ClinGen TOPMed gnomAD
CA404444416 rs1423328946	335	E>Q		No	ClinGen gnomAD
rs767875619 CA9254450	336	Q>E		No	ClinGen ExAC gnomAD
CA9254449 rs201154155	336	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA9254444 rs1555725397	337	V>A		No	ClinGen Ensembl
CA9254446 rs150137137	337	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9254447 rs150137137	337	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1220264154 CA404444398	338	L>F		No	ClinGen gnomAD
rs775128939 CA9254443	339	P>L		No	ClinGen ExAC TOPMed gnomAD
CA404444385 rs1415639159	340	I>R		No	ClinGen TOPMed
rs769622044 CA9254442	340	I>V		No	ClinGen ExAC TOPMed gnomAD
rs768069872 CA9254441	341	I>L		No	ClinGen ExAC gnomAD

No associated diseases with P25685

3 regional properties for P25685

Type	Name	Position	InterPro Accession
domain	DnaJ domain	3 - 79	IPR001623
domain	Chaperone DnaJ, C-terminal	164 - 323	IPR002939
conserved_site	DnaJ domain, conserved site	45 - 64	IPR018253

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Nucleus, nucleolus	Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
sperm head	The part of the late spermatid or spermatozoon that contains the nucleus and acrosome.

9 GO annotations of molecular function

Name	Definition
ATPase activator activity	Binds to and increases the activity of an ATP hydrolysis activity.
ATPase binding	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
Hsp70 protein binding	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
transcription regulator inhibitor activity	A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.
unfolded protein binding	Binding to an unfolded protein.

8 GO annotations of biological process

Name	Definition
cellular response to heat	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
chaperone cofactor-dependent protein refolding	The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
forebrain development	The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
negative regulation of inclusion body assembly	Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of ATP-dependent activity	Any process that activates or increases the rate of an ATP-dependent activity.
regulation of cellular response to heat	Any process that modulates the frequency, rate or extent of cellular response to heat.
response to unfolded protein	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MGKDYYQTLG	LARGASDEEI	KRAYRRQALR	YHPDKNKEPG	AEEKFKEIAE	AYDVLSDPRK
70	80	90	100	110	120
REIFDRYGEE	GLKGSGPSGG	SGGGANGTSF	SYTFHGDPHA	MFAEFFGGRN	PFDTFFGQRN
130	140	150	160	170	180
GEEGMDIDDP	FSGFPMGMGG	FTNVNFGRSR	SAQEPARKKQ	DPPVTHDLRV	SLEEIYSGCT
190	200	210	220	230	240
KKMKISHKRL	NPDGKSIRNE	DKILTIEVKK	GWKEGTKITF	PKEGDQTSNN	IPADIVFVLK
250	260	270	280	290	300
DKPHNIFKRD	GSDVIYPARI	SLREALCGCT	VNVPTLDGRT	IPVVFKDVIR	PGMRRKVPGE
310	320	330
GLPLPKTPEK	RGDLIIEFEV	IFPERIPQTS	RTVLEQVLPI