P25576
Gene name |
POF1 |
Protein name |
Nicotinamide mononucleotide adenylyltransferase |
Names |
NMN adenylyltransferase, NMNAT, NMN-specific adenylyltransferase, Promoter of filamentation protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YCL047C |
EC number |
2.7.7.1: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P25576
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P25576-F1 | Predicted | AlphaFoldDB |
4 variants for P25576
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s03-44055 | 128 | G>E | No | SGRP | |
| s03-43938 | 167 | S>C | No | SGRP | |
| s03-43915 | 175 | G>S | No | SGRP | |
| s03-43743 | 232 | N>S | No | SGRP |
No associated diseases with P25576
1 regional properties for P25576
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytidyltransferase-like domain | 33 - 228 | IPR004821 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.1 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| nicotinamide-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| invasive growth in response to glucose limitation | A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae. |
| NAD biosynthesis via nicotinamide riboside salvage pathway | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside. |
| pseudohyphal growth | The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKKTFEQFRK | SNLLFQVLKG | PQHLECQKLF | VLDSSFNPPH | LAHFQLLSQT | IKNFKLKDTR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SHVLLLLAVN | NADKLPKPAS | FPTRLEMMCL | FADYLQEKLP | QSVVSVGLTV | FSKFIDKDKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHEQFVKGCS | ADIGYLVGFD | TIARIFDEKY | YHPLKISDVM | ESFMSGSQLY | CLARGDCHLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AESQLRYASD | ILEGKFEPVI | PREWGARIHV | MQNDYPALRN | VSSSEIRNKL | KNGQVESLKD |
| 250 | |||||
| ELPLCIYDYL | INNKTIFD |