P25390

PR
Gene name
SSK22 (YCR073C, YCR73C)
Protein name
Serine/threonine-protein kinase SSK22
Names
MAP kinase kinase kinase SSK22, Suppressor of sensor kinase 22
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YCR073C
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

931-1036 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

1175-1185 (Activation loop from InterPro)

Target domain

1034-1310 (Protein kinase domain)

Relief mechanism

Assay

1208-1214 (Activation loop from InterPro)

Target domain

1034-1310 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P25390

Entry ID Method Resolution Chain Position Source
AF-P25390-F1 Predicted AlphaFoldDB

60 variants for P25390

Variant ID(s) Position Change Description Diseaes Association Provenance
s03-246481 34 S>P No SGRP
s03-246475 36 H>D No SGRP
s03-246429 51 G>D No SGRP
s03-246416 55 I>M No SGRP
s03-246406 59 P>S No SGRP
s03-246274 103 G>S No SGRP
s03-246266 105 D>E No SGRP
s03-246180 134 R>M No SGRP
s03-246168 138 S>L No SGRP
s03-245901 227 M>T No SGRP
s03-245892 230 Q>R No SGRP
s03-245853 243 E>A No SGRP
s03-245821 254 H>D No SGRP
s03-245759 274 N>K No SGRP
s03-245734 283 D>Y No SGRP
s03-245718 288 W>L No SGRP
s03-245649 311 P>L No SGRP
s03-245628 318 C>F No SGRP
s03-245584 333 K>E No SGRP
s03-245461 374 T>A No SGRP
s03-245460 374 T>I No SGRP
s03-245431 384 Y>H No SGRP
s03-245362 407 S>T No SGRP
s03-245296 429 A>S No SGRP
s03-245235 449 P>Q No SGRP
s03-245032 517 L>V No SGRP
s03-244983 533 K>R No SGRP
s03-244918 555 F>L No SGRP
s03-244885 566 N>D No SGRP
s03-244879 568 F>L No SGRP
s03-244728 618 A>V No SGRP
s03-244423 720 E>Q No SGRP
s03-244369 738 E>K No SGRP
s03-244300 761 D>N No SGRP
s03-244293 763 G>E No SGRP
s03-244282 767 N>H No SGRP
s03-244278 768 P>Q No SGRP
s03-244171 804 C>S No SGRP
s03-244164 806 L>P No SGRP
s03-244070 837 S>R No SGRP
s03-243977 868 F>L No SGRP
s03-243925 886 N>Y No SGRP
s03-243894 896 D>V No SGRP
s03-243777 935 E>G No SGRP
s03-243684 966 R>K No SGRP
s03-243561 1007 G>D No SGRP
s03-243450 1044 T>I No SGRP
s03-243435 1049 Y>C No SGRP
s03-243409 1058 E>K No SGRP
s03-243318 1088 E>G No SGRP
s03-243256 1109 N>D No SGRP
s03-243221 1120 L>F No SGRP
s03-243216 1122 S>L No SGRP
s03-243181 1134 V>I No SGRP
s03-243141 1147 A>V No SGRP
s03-243139 1148 Y>H No SGRP
s03-242914 1223 G>S No SGRP
s03-242883 1233 D>G No SGRP
s03-242677 1302 V>M No SGRP
s03-242601 1327 P>L No SGRP

No associated diseases with P25390

3 regional properties for P25390

Type Name Position InterPro Accession
domain Protein kinase domain 1034 - 1310 IPR000719
active_site Serine/threonine-protein kinase, active site 1154 - 1166 IPR008271
binding_site Protein kinase, ATP binding site 1040 - 1063 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

4 GO annotations of biological process

Name Definition
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
osmosensory signaling MAPK cascade The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K.
p38MAPK cascade An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41279 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Homo sapiens (Human) EV
Q07174 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Mus musculus (Mouse) SS
Q63562 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MMMDILNTQQ QKAAEGGRVL APHTISSKLV KRLSSHSSHK LSRSDLKALG GSETISDGPS
70 80 90 100 110 120
QLTFKDRYVF NESLYLKKLK KTALDDYYTR GIKLTNRYEE DDGDDEIIRL SNGDRIDEDL
130 140 150 160 170 180
HSGVKFFSTT PYCRKMRSDS DELAWNEIAT ERFKWQSMLA RVLKGDIVKG EKTRIANQVK
190 200 210 220 230 240
KPGLNKELSD EIWLELKAWL NGRTMQEMEQ SLTYLRDSSD SVFEEIMKFQ IPQGKILSLD
250 260 270 280 290 300
ALEAILQDLM NRYHSVVSYW PNLKKMYKDK PITNTAEFTA RIDVMNSWLN FKTNLTLRRQ
310 320 330 340 350 360
ELDDWINRFS PISSSDNCQE DFDGVPQWNC KMKILAEQLM KEKNIESIFQ KKIFYPLSPW
370 380 390 400 410 420
MFKLKLHFIV YRETLTKMNI KYPYERLRSL LAFPVYLIKE VILTRLSYAR KLKNPTMMMI
430 440 450 460 470 480
DQMIDDFNAF IRLSVQLKYT LTKYCSNLPF DVDFDPTFEN TVIEAIRYLF FLLNLKLIDS
490 500 510 520 530 540
SKQNFKAPDL LLKYWDHLKN TGHYINGAET VIPNEFLKLT LRLVHKLQFY LLKQQNFPPT
550 560 570 580 590 600
FANASEAEKW LSSIFENLGA MKRKLNRFSN ILVKAFQNSA VYQINHNAQL VKKLKDAHYF
610 620 630 640 650 660
LVYSGNTFES SGVYMFAAPE LLGCDNDTIL RILRNKSIGC DLVPKLDIGN NLNVYDITTK
670 680 690 700 710 720
ETDLNILVSK GEDSKGIPYY RVVANSSSDL DRHAHQSKKK NFSTDPFDQH LDEKNNEVFE
730 740 750 760 770 780
LEVALSSLGA LVVLYPGEPV VWDGPVYKLP GNNLFASNEM DLGKIGNPNT LILLNQGSNY
790 800 810 820 830 840
ALTYQIDKFN QTVGDSVSFI EKRCSLNSIE SSLQKINKAY YKLTYTVLNN YKGILGSFMK
850 860 870 880 890 900
QCPGNELLNS IFMFGRDFGR SFLKYNAFSS KRKYVIIFLM VKLGMNWLKF LVEECDPTDQ
910 920 930 940 950 960
RTFRWCVLAM DFAMQMTSGY NILALNVKQF QELKERVSVC MSLLISHFDV MGARATEAEN
970 980 990 1000 1010 1020
GMQQARLNID TEENIDEEAT LEINSRLRLE AIKTLEKTMK RNPRQMGKVL DATDQGNKYL
1030 1040 1050 1060 1070 1080
LSLASSLSNV SMRWQKRSFI GGGTFGQVYS AINLENGEIL AVKEIKIHDT TTMKKIFPLI
1090 1100 1110 1120 1130 1140
KEEMTVLEML NHPNIVQYYG VEVHRDKVNI FMEYCEGGSL ASLLDHGRIE DEMVTQVYTF
1150 1160 1170 1180 1190 1200
ELLEGLAYLH QSGVVHRDIK PENILLDFNG IIKYVDFGTA RTVVGSRTRT VRNAAVQDFG
1210 1220 1230 1240 1250 1260
VETKSLNEMM GTPMYMAPET ISGSAVKGKL GADDVWALGC VVLEMATGRR PWSNLDNEWA
1270 1280 1290 1300 1310 1320
IMYHVAAGRI PQLPNRDEMT AAGRAFLERC LVQDPTMRAT AVELLIDPWM IQIREIAFGN
1330
SEKDQVPILS S