P25378

PR
Gene name
RHB1 (RSG1, YCR027C, YCR27C)
Protein name
Rheb-like protein RHB1
Names
GTP-binding protein RSG1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YCR027C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P25378

Entry ID Method Resolution Chain Position Source
AF-P25378-F1 Predicted AlphaFoldDB

6 variants for P25378

Variant ID(s) Position Change Description Diseaes Association Provenance
s03-167872 42 V>L No SGRP
s03-167807 63 D>E No SGRP
s03-167737 87 G>S No SGRP
s03-167720 92 I>M No SGRP
s03-167590 136 S>G No SGRP
s03-167586 137 T>I No SGRP

No associated diseases with P25378

1 regional properties for P25378

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 17 - 184 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Cell periphery, adjacent to the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

4 GO annotations of biological process

Name Definition
L-arginine transmembrane transport The directed movement of L-arginine across a membrane.
lysine transport The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEYATMSSSN STHNFQRKIA LIGARNVGKT TLTVRFVESR FVESYYPTIE NEFTRIIPYK
70 80 90 100 110 120
SHDCTLEILD TAGQDEVSLL NIKSLTGVRG IILCYSIINR ASFDLIPILW DKLVDQLGKD
130 140 150 160 170 180
NLPVILVGTK ADLGRSTKGV KRCVTKAEGE KLASTIGSQD KRNQAAFIEC SAELDYNVEE
190 200
TFMLLLKQME RVEGTLGLDA ENNNKCSIM