P25336
PR
Gene name |
MSH3 (YCR092C, YCR1152, YCR92C) |
Protein name |
DNA mismatch repair protein MSH3 |
Names |
Mismatch-binding protein, MBP, MutS protein homolog 3 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YCR092C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P25336
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P25336-F1 | Predicted | AlphaFoldDB |
24 variants for P25336
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s03-279813 | 2 | A>V | No | SGRP | |
| s03-279625 | 65 | G>C | No | SGRP | |
| s03-279624 | 65 | G>D | No | SGRP | |
| s03-279478 | 114 | E>K | No | SGRP | |
| s03-279315 | 168 | T>M | No | SGRP | |
| s03-279283 | 179 | P>S | No | SGRP | |
| s03-279255 | 188 | N>S | No | SGRP | |
| s03-279252 | 189 | P>L | No | SGRP | |
| s03-279105 | 238 | G>A | No | SGRP | |
| s03-278949 | 290 | V>A | No | SGRP | |
| s03-278869 | 317 | D>N | No | SGRP | |
| s03-278823 | 332 | V>A | No | SGRP | |
| s03-278788 | 344 | A>T | No | SGRP | |
| s03-278659 | 387 | V>I | No | SGRP | |
| s03-278652 | 389 | K>R | No | SGRP | |
| s03-278459 | 453 | L>F | No | SGRP | |
| s03-278425 | 465 | V>I | No | SGRP | |
| s03-278148 | 557 | P>L | No | SGRP | |
| s03-278136 | 561 | R>K | No | SGRP | |
| s03-278097 | 574 | Q>R | No | SGRP | |
| s03-277892 | 642 | N>K | No | SGRP | |
| s03-277447 | 791 | G>R | No | SGRP | |
| s03-277381 | 813 | I>V | No | SGRP | |
| s03-276789 | 1010 | A>V | No | SGRP |
No associated diseases with P25336
5 regional properties for P25336
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA mismatch repair protein MutS, C-terminal | 784 - 978 | IPR000432 |
| domain | DNA mismatch repair protein MutS-like, N-terminal | 133 - 260 | IPR007695 |
| domain | DNA mismatch repair protein MutS, core | 423 - 768 | IPR007696 |
| domain | DNA mismatch repair protein MutS, connector domain | 276 - 403 | IPR007860 |
| domain | DNA mismatch repair protein MutS, clamp | 611 - 689 | IPR007861 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| MutSbeta complex | A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| DNA insertion or deletion binding | Binding to a double-stranded DNA region containing an insertion or a deletion. |
| double-strand/single-strand DNA junction binding | Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA. |
| double-stranded DNA binding | Binding to double-stranded DNA. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| meiotic mismatch repair | A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. |
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
| mitotic recombination | The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. |
| removal of nonhomologous ends | The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. |
| replication fork arrest | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20585 | MSH3 | DNA mismatch repair protein Msh3 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGQPTISRF | FKKAVKSELT | HKQEQEVAVG | NGAGSESICL | DTDEEDNLSS | VASTTVTNDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPLKGSVSSK | NSKNSEKTSG | TSTTFNDIDF | AKKLDRIMKR | RSDENVEAED | DEEEGEEDFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKKARKSPTA | KLTPLDKQVK | DLKMHHRDKV | LVIRVGYKYK | CFAEDAVTVS | RILHIKLVPG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLTIDESNPQ | DCNHRQFAYC | SFPDVRLNVH | LERLVHHNLK | VAVVEQAETS | AIKKHDPGAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSSVFERKIS | NVFTKATFGV | NSTFVLRGKR | ILGDTNSIWA | LSRDVHQGKV | AKYSLISVNL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NNGEVVYDEF | EEPNLADEKL | QIRIKYLQPI | EVLVNTDDLP | LHVAKFFKDI | SCPLIHKQEY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DLEDHVVQAI | KVMNEKIQLS | PSLIRLVSKL | YSHMVEYNNE | QVMLIPSIYS | PFASKIHMLL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DPNSLQSLDI | FTHDGGKGSL | FWLLDHTRTS | FGLRMLREWI | LKPLVDVHQI | EERLDAIECI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TSEINNSIFF | ESLNQMLNHT | PDLLRTLNRI | MYGTTSRKEV | YFYLKQITSF | VDHFKMHQSY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LSEHFKSSDG | RIGKQSPLLF | RLFSELNELL | STTQLPHFLT | MINVSAVMEK | NSDKQVMDFF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NLNNYDCSEG | IIKIQRESES | VRSQLKEELA | EIRKYLKRPY | LNFRDEVDYL | IEVKNSQIKD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LPDDWIKVNN | TKMVSRFTTP | RTQKLTQKLE | YYKDLLIRES | ELQYKEFLNK | ITAEYTELRK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ITLNLAQYDC | ILSLAATSCN | VNYVRPTFVN | GQQAIIAKNA | RNPIIESLDV | HYVPNDIMMS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PENGKINIIT | GPNMGGKSSY | IRQVALLTIM | AQIGSFVPAE | EIRLSIFENV | LTRIGAHDDI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| INGDSTFKVE | MLDILHILKN | CNKRSLLLLD | EVGRGTGTHD | GIAISYALIK | YFSELSDCPL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ILFTTHFPML | GEIKSPLIRN | YHMDYVEEQK | TGEDWMSVIF | LYKLKKGLTY | NSYGMNVAKL |
| 970 | 980 | 990 | 1000 | 1010 | |
| ARLDKDIINR | AFSISEELRK | ESINEDALKL | FSSLKRILKS | DNITATDKLA | KLLSLDIH |