AiPD: Autoinhibited Protein Database

Gene name	lasR (PA1430)
Protein name	Transcriptional activator protein LasR
Names
Species	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway	pae:PA1430
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

133-203 (Predicted disordered autoinhibitory region) PR

133-203 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
2UV0	X-ray	180 A	E/F/G/H	1-173	PDB
3IX3	X-ray	140 A	A/B	1-173	PDB
3IX4	X-ray	180 A	A/B/C/D/E/F/G/H	1-173	PDB
3IX8	X-ray	180 A	A/B/C/D	1-173	PDB
3JPU	X-ray	230 A	A/B/C/D/E	1-173	PDB
4NG2	X-ray	241 A	A/B/C/D	1-170	PDB
6D6A	X-ray	190 A	A/B/C/D/E/F/G/H	1-170	PDB
6D6B	X-ray	170 A	A/B/C/D/E/F/G/H	1-170	PDB
6D6C	X-ray	188 A	A/B/C/D/E/F/G/H/I/J/K/L	1-170	PDB
6D6D	X-ray	170 A	A/B	1-169	PDB
6D6L	X-ray	163 A	A/B/C/D	1-170	PDB
6D6M	X-ray	190 A	A/B/C/D	1-170	PDB
6D6N	X-ray	181 A	A/B/C/D	1-170	PDB
6D6O	X-ray	165 A	A/B/C/D	1-170	PDB
6D6P	X-ray	165 A	A/B/C/D	1-170	PDB
6MWH	X-ray	220 A	A/B	1-239	PDB
6MWL	X-ray	150 A	A/B	1-239	PDB
6MWW	X-ray	276 A	A/B	1-239	PDB
6MWZ	X-ray	166 A	A/B	1-239	PDB
6V7W	X-ray	300 A	B/E	1-239	PDB
6V7X	X-ray	290 A	B	1-239	PDB
AF-P25084-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
	144	M>I	strain: IFO 3455 and PA103 [UniProt]	No
	180	R>W	strain: PA103 [UniProt]	No

Type	Name	Position	InterPro Accession
domain	Transcription regulator LuxR, C-terminal	170 - 235	IPR000792
domain	Transcription factor LuxR-like, autoinducer-binding domain	18 - 160	IPR005143

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
protein-DNA complex	A macromolecular complex containing both protein and DNA molecules.

Name	Definition
DNA-binding transcription activator activity	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Name	Definition
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of elastin biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin.
quorum sensing	The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of elastin catabolic process	Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins