P24799
Gene name |
gnas |
Protein name |
Guanine nucleotide-binding protein G(s) subunit alpha |
Names |
Adenylate cyclase-stimulating G alpha protein |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:394414 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P24799
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P24799-F1 | Predicted | AlphaFoldDB |
No variants for P24799
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P24799 | |||||
No associated diseases with P24799
No regional properties for P24799
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P24799 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| G-protein beta/gamma-subunit complex binding | Binding to a complex of G-protein beta/gamma subunits. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGCLGNSKTE | DQRNEEKVQR | ETNKKIEKQL | QKDKQVYRAT | HRLLLLGAGE | SGKSSIVKQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RILHVNGFNA | EEKKTKVQDI | KNNIKEAIET | IVTAMGNLSP | PVELVNPENQ | FRIDYILNLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NYKDFEFSPE | FYEHTKTLWQ | DEGVRACYER | SNEYQLIDCA | QYFLDKIDIV | KQNDYTPSDQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLLRCRVLTS | GIFETKFQVD | KVNFHMFDVG | GQRDERRKWI | QCFNDVTAII | FVVASSSYNM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIREDNHTNR | LQEALNLFKS | IWNNRWLRTI | SVILFLNKQD | LLAEKVNAGK | SKIEDYFPEF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARYTTPDDAT | PEVGEDPRVT | RAKYFIRDEF | LRISTASGDG | RHYCYPHFTC | AVDTENIRRV |
| 370 | |||||
| FNDCRDIIQR | MHLRQYELL |