AiPD: Autoinhibited Protein Database

Gene name	ERG8
Protein name	Phosphomevalonate kinase
Names
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YMR220W
EC number	2.7.4.2: Phosphotransferases with a phosphate group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

96-180 (Predicted disordered autoinhibitory region) PR

96-180 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P24521-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s13-712384	24	T>P	No	SGRP
s13-712460	49	G>E	No	SGRP
s13-712538	75	S>T	No	SGRP
s13-712618	102	K>E	No	SGRP
s13-712632	106	D>E	No	SGRP
s13-712635	107	D>E	No	SGRP
s13-712646	111	R>T	No	SGRP
s13-712717	135	R>C	No	SGRP
s13-712888	192	A>S	No	SGRP
s13-713011	233	I>V	No	SGRP
s13-713023	237	T>S	No	SGRP
s13-713044	244	H>Y	No	SGRP
s13-713053	247	D>N	No	SGRP
s13-713062	250	D>N	No	SGRP
s13-713101	263	G>R	No	SGRP
s13-713467	385	Q>E	No	SGRP
s13-713536	408	T>A	No	SGRP
s13-713561	416	A>D	No	SGRP
s13-713572	420	N>D	No	SGRP
s13-713636	441	K>R	No	SGRP
s13-713659	449	L>F	No	SGRP

Type	Name	Position	InterPro Accession
conserved_site	GHMP kinase, ATP-binding, conserved site	150 - 160	IPR006203
domain	GHMP kinase N-terminal domain	149 - 216	IPR006204
domain	GHMP kinase, C-terminal domain	360 - 412	IPR013750

		Description
EC Number	2.7.4.2	Phosphotransferases with a phosphate group as acceptor
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphomevalonate kinase activity	Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+).

Name	Definition
ergosterol biosynthetic process	The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
farnesyl diphosphate biosynthetic process, mevalonate pathway	The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols.
isopentenyl diphosphate biosynthetic process, mevalonate pathway	The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.
organic acid phosphorylation	The process of introducing one or more phosphate groups into an organic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins