P24322
Gene name |
al-3 (B8P8.010, NCU01427) |
Protein name |
Geranylgeranyl pyrophosphate synthase |
Names |
GGPP synthase, GGPPSase, (2E,6E)-farnesyl diphosphate synthase, Albino-3 protein, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU01427 |
EC number |
2.5.1.1: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P24322
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P24322-F1 | Predicted | AlphaFoldDB |
No variants for P24322
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P24322 | |||||
No associated diseases with P24322
2 regional properties for P24322
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Polyprenyl synthetase, conserved site | 183 - 197 | IPR033749-1 |
| conserved_site | Polyprenyl synthetase, conserved site | 302 - 314 | IPR033749-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.1 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| dimethylallyltranstransferase activity | Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. |
| farnesyltranstransferase activity | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| geranyltranstransferase activity | Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. |
| metal ion binding | Binding to a metal ion. |
| prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| carotenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. |
| farnesyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. |
| geranyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of geranyl diphosphate. |
| geranylgeranyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate. |
| isoprenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. |
| isoprenoid metabolic process | The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHVTMAVTS | SSPGPAPLSL | LSNNDDFIAP | FNINTKFPSA | IVPPRTSSNQ | PISVAIPSNR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ISSAGLAATQ | QAQTRKRKAS | VAQISLPSML | PTSFSPYTMA | PQPPQPPPNP | DRFATEDFFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSRRTWSEEK | EKVLTGPYDY | LNGHPGKDIR | SQMVKAFDAW | LDVPSESLEV | ITKVISMLHT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASLLVDDVED | NSVLRRGFPV | AHSIFGIPQT | INTSNYVYFY | ALQELQKLKN | PKAVSIFSEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLNLHRGQGM | DLFWRDTLTC | PTEDDYLEMV | SNKTGGLFRL | GIKLMQAESR | SPVDCVPLVN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IIGLIFQIAD | DYHNLWNREY | TANKGMCEDL | TEGKFSFPVI | HSIRSNPSNM | QLLNILKQKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GDEEVKRYAV | AYMESTGSFE | YTRKVIKVLV | DRARQMTEDI | DDGRGKSGGI | HKILDRIMLH |
| 430 | |||||
| QEENVAQKNG | KKE |