P24230
Gene name |
recG (radC) |
Protein name |
ATP-dependent DNA helicase RecG |
Names |
|
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b3652 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P24230
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P24230-F1 | Predicted | AlphaFoldDB |
No variants for P24230
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P24230 | |||||
No associated diseases with P24230
5 regional properties for P24230
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 481 - 628 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 273 - 433 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 265 - 459 | IPR014001 |
| domain | RecG, wedge domain | 15 - 171 | IPR033454 |
| domain | ATP-dependent DNA helicase RecG, domain 3, C-terminal | 617 - 676 | IPR045562 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Holliday junction helicase complex | A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA duplex unwinding | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. |
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| response to radiation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKGRLLDAVP | LSSLTGVGAA | LSNKLAKINL | HTVQDLLLHL | PLRYEDRTHL | YPIGELLPGV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YATVEGEVLN | CNISFGGRRM | MTCQISDGSG | ILTMRFFNFS | AAMKNSLAAG | RRVLAYGEAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGKYGAEMIH | PEYRVQGDLS | TPELQETLTP | VYPTTEGVKQ | ATLRKLTDQA | LDLLDTCAIE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELLPPELSQG | MMTLPEALRT | LHRPPPTLQL | SDLETGQHPA | QRRLILEELL | AHNLSMLALR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AGAQRFHAQP | LSANDTLKNK | LLAALPFKPT | GAQARVVAEI | ERDMALDVPM | MRLVQGDVGS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKTLVAALAA | LRAIAHGKQV | ALMAPTELLA | EQHANNFRNW | FAPLGIEVGW | LAGKQKGKAR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAQQEAIASG | QVQMIVGTHA | IFQEQVQFNG | LALVIIDEQH | RFGVHQRLAL | WEKGQQQGFH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PHQLIMTATP | IPRTLAMTAY | ADLDTSVIDE | LPPGRTPVTT | VAIPDTRRTD | IIDRVHHACI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TEGRQAYWVC | TLIEESELLE | AQAAEATWEE | LKLALPELNV | GLVHGRMKPA | EKQAVMASFK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QGELHLLVAT | TVIEVGVDVP | NASLMIIENP | ERLGLAQLHQ | LRGRVGRGAV | ASHCVLLYKT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PLSKTAQIRL | QVLRDSNDGF | VIAQKDLEIR | GPGELLGTRQ | TGNAEFKVAD | LLRDQAMIPE |
| 670 | 680 | 690 | |||
| VQRLARHIHE | RYPQQAKALI | ERWMPETERY | SNA |