P24053
Gene name |
Nmbr |
Protein name |
Neuromedin-B receptor |
Names |
NMB-R, Neuromedin-B-preferring bombesin receptor |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25264 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P24053
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P24053-F1 | Predicted | AlphaFoldDB |
1 variants for P24053
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8169760 | 56 | V>L | No | EVA |
No associated diseases with P24053
1 regional properties for P24053
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Olfactomedin-like domain | 230 - 489 | IPR003112 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| bombesin receptor activity | Combining with bombesin to initiate a change in cell activity. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| neuropeptide receptor activity | Combining with a neuropeptide to initiate a change in cell activity. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| antiviral innate immune response | A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| negative regulation of interleukin-6 production | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. |
| positive regulation of interferon-alpha production | Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. |
| positive regulation of osteoclast proliferation | Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. |
| positive regulation of respiratory gaseous exchange | Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. |
| sneeze reflex | A reflex process that expels air forcibly from the mouth and nose in an explosive, spasmodic involuntary action resulting chiefly from irritation of the nasal mucous membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPRSLPNLS | LPTEASESEL | EPEVWENDFL | PDSDGTTAEL | VIRCVIPSLY | LIIISVGLLG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NIMLVKIFLT | NSTMRSVPNI | FISNLAAGDL | LLLLTCVPVD | ASRYFFDEWV | FGKLGCKLIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIQLTSVGVS | VFTLTALSAD | RYRAIVNPMD | MQTSGVVLWT | SLKAVGIWVV | SVLLAVPEAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FSEVARIGSS | DNSSFTACIP | YPQTDELHPK | IHSVLIFLVY | FLIPLVIISI | YYYHIAKTLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RSAHNLPGEY | NEHTKKQMET | RKRLAKIVLV | FVGCFVFCWF | PNHILYLYRS | FNYKEIDPSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GHMIVTLVAR | VLSFSNSCVN | PFALYLLSES | FRKHFNSQLC | CGQKSYPERS | TSYLLSSSAV |
| 370 | 380 | ||||
| RMTSLKSNAK | NVVTNSVLLN | GHSTKQEIAL |