AiPD: Autoinhibited Protein Database

P24001

Gene name	IL32 (NK4, TAIF)
Protein name	Interleukin-32
Names	IL-32, Natural killer cells protein 4, Tumor necrosis factor alpha-inducing factor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9235
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

90-163 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

90-163 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P24001

Entry ID	Method	Resolution	Chain	Position	Source
AF-P24001-F1	Predicted				AlphaFoldDB

380 variants for P24001

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1180512486 CA394450180	3	F>S		No	ClinGen gnomAD
rs755307247 CA7856622	4	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7856623 rs755307247	4	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1411811415 CA394450186	4	P>S		No	ClinGen gnomAD
CA7856625 rs770405203	5	K>E		No	ClinGen ExAC gnomAD
rs114354531 CA394451386	6	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs114354531 COSM3690958 CA7856663 COSM3690959 RCV000968724	6	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA394451388 rs114354531	6	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394451411 rs1337467275	8	S>P		No	ClinGen gnomAD
rs746682981 CA7856664	10	D>A		No	ClinGen ExAC TOPMed gnomAD
rs1230006322 CA394451459	11	M>I		No	ClinGen gnomAD
TCGA novel	11	M>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394451457 rs1327280613	11	M>T		No	ClinGen gnomAD
rs372604790 CA7856665	11	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs547829248 CA394451527	15	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773196760 CA7856669	16	A>D		No	ClinGen ExAC TOPMed gnomAD
CA394451540 rs773196760	16	A>V		No	ClinGen ExAC TOPMed gnomAD
rs774458382 CA394451544	17	R>*		No	ClinGen ExAC TOPMed gnomAD
rs774458382 CA7856672	17	R>G		No	ClinGen ExAC TOPMed gnomAD
CA7856673 rs561371637	17	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1375788136 CA394451562	18	M>K		No	ClinGen gnomAD
rs767794140 CA7856674	18	M>L		No	ClinGen ExAC gnomAD
rs752796018 CA7856675	19	V>L		No	ClinGen ExAC
CA7856678 rs113075507	20	M>I		No	ClinGen ExAC gnomAD
rs764542270 CA7856677	20	M>T		No	ClinGen ExAC gnomAD
rs761171126 CA7856676	20	M>V		No	ClinGen ExAC gnomAD
rs1354702133 CA394451602	21	L>F		No	ClinGen TOPMed
rs757809713 CA7856680	21	L>P		No	ClinGen ExAC TOPMed gnomAD
RCV000900852 rs769602896	22	L>missing		No	ClinVar dbSNP
rs55756224 CA7856682	22	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1567142932 CA620712348	22	L>F		No	ClinGen Ensembl
rs754385064 CA7856683	23	P>S		No	ClinGen ExAC gnomAD
rs1018972379 CA276878244	24	T>A		No	ClinGen TOPMed
rs1490939230 CA394451645	24	T>S		No	ClinGen TOPMed gnomAD
CA7856685 rs201900317	25	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276878259 rs201900317	25	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276878255 rs936563185	25	S>P		No	ClinGen TOPMed gnomAD
CA394451666 rs1327735225	26	A>D		No	ClinGen TOPMed gnomAD
rs755957701 CA7856687	27	Q>*		No	ClinGen ExAC gnomAD
rs913522456 CA276878273	27	Q>P		No	ClinGen gnomAD
rs1485988682 CA394451691	28	G>R		No	ClinGen TOPMed gnomAD
CA394451725 rs1199920264	30	G>E		No	ClinGen gnomAD
CA7856691 rs371706904	30	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs745965931 CA7856694	31	A>P		No	ClinGen ExAC TOPMed gnomAD
rs745965931 CA7856693	31	A>T		No	ClinGen ExAC TOPMed gnomAD
CA394451750 rs1364523600	32	W>S		No	ClinGen TOPMed gnomAD
rs1161723321 CA394451765	33	V>A		No	ClinGen gnomAD
rs951472884 CA276878347	33	V>I		No	ClinGen TOPMed gnomAD
rs376323814 CA394451772	34	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs376323814 CA7856695	34	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs760959135 CA394451787	35	A>E		No	ClinGen ExAC TOPMed gnomAD
rs760959135 CA7856696	35	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1349098419 CA394451801	36	C>Y		No	ClinGen gnomAD
rs868507983 CA276878383	37	D>G		No	ClinGen Ensembl
rs1374139568 CA394451812	37	D>H		No	ClinGen TOPMed
rs539684284 CA7856700	39	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750824317 CA7856701	40	D>G		No	ClinGen ExAC TOPMed gnomAD
CA394451841 rs1263274099	40	D>N		No	ClinGen gnomAD
CA7856702 rs754580611	41	T>S		No	ClinGen ExAC gnomAD
CA7856704 rs752442725	42	V>A		No	ClinGen ExAC TOPMed gnomAD
CA394451856 rs752442725	42	V>E		No	ClinGen ExAC TOPMed gnomAD
CA394451859 rs752442725	42	V>G		No	ClinGen ExAC TOPMed gnomAD
CA7856703 rs766919795	42	V>M		No	ClinGen ExAC gnomAD
CA7856706 rs777364422	43	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1185544689 CA394451869	43	G>V		No	ClinGen gnomAD
CA394451877 rs1384785063	44	H>Y		No	ClinGen gnomAD
rs749103415 CA7856707	46	G>E		No	ClinGen ExAC gnomAD
CA7856709 rs778976584	48	W>*		No	ClinGen ExAC TOPMed gnomAD
CA7856708 rs756980976	48	W>R		No	ClinGen ExAC gnomAD
rs1429649864 CA394451944	49	R>K		No	ClinGen gnomAD
CA276878496 rs916507315	50	D>A		No	ClinGen TOPMed
CA394451962 rs1596251827	50	D>H		No	ClinGen Ensembl
TCGA novel	50	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7856711 rs772245098	51	K>E		No	ClinGen ExAC TOPMed gnomAD
rs775405103 CA7856712	51	K>N		No	ClinGen ExAC TOPMed gnomAD
CA394451982 rs1317517901	51	K>R		No	ClinGen TOPMed
rs201114894 CA394451995	52	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201114894 CA7856713	52	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs566802763 CA7856714	53	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394452044 rs762269785	54	A>G		No	ClinGen ExAC gnomAD
CA7856716 rs762269785	54	A>V		No	ClinGen ExAC gnomAD
rs773824307 CA394452051	55	L>F		No	ClinGen ExAC TOPMed gnomAD
rs773824307 CA7856718	55	L>V		No	ClinGen ExAC TOPMed gnomAD
rs767093013 CA276878581 CA7856720	56	W>C		No	ClinGen ExAC TOPMed gnomAD
CA7856719 rs763343691	56	W>S		No	ClinGen ExAC TOPMed gnomAD
CA7856721 rs752233130	57	C>Y		No	ClinGen ExAC gnomAD
rs760128612 CA7856722	58	Q>E		No	ClinGen ExAC gnomAD
rs763748487 CA7856723	58	Q>H		No	ClinGen ExAC gnomAD
rs962309213 CA276878614	59	L>F		No	ClinGen gnomAD
CA394452135 rs962309213	59	L>V		No	ClinGen gnomAD
rs1428246824 CA394452166	60	C>*		No	ClinGen TOPMed gnomAD
CA394452159 rs1185714861	60	C>R		No	ClinGen gnomAD
CA394452164 rs1388676429	60	C>S		No	ClinGen gnomAD
CA7856724 rs753486240	61	L>F		No	ClinGen ExAC gnomAD
CA7856726 rs778552874	61	L>P		No	ClinGen ExAC TOPMed gnomAD
CA276878631 rs778552874	61	L>R		No	ClinGen ExAC TOPMed gnomAD
rs753486240 CA7856725	61	L>V		No	ClinGen ExAC gnomAD
rs758302498 CA7856728	62	S>F		No	ClinGen ExAC gnomAD
rs555441503 CA7856727	62	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394452241 rs1247123625	64	Q>H		No	ClinGen TOPMed gnomAD
rs370139293 CA7856729	64	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA394452262 rs1474382960	65	H>Q		No	ClinGen TOPMed
rs747102738 CA7856730	65	H>R		No	ClinGen ExAC gnomAD
rs1167376425 CA394452250	65	H>Y		No	ClinGen TOPMed
rs954767005 CA276878649 CA394452294	66	Q>H		No	ClinGen gnomAD
CA7856731 rs768786551	67	A>P		No	ClinGen ExAC gnomAD
CA7856732 rs115923319 RCV000957361	68	I>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7856733 rs748365535	68	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs115923319 CA394452316	68	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	69	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139541431 CA7856734	69	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs910339811 CA276878660	69	E>K		No	ClinGen TOPMed
rs910339811 CA394452337	69	E>Q		No	ClinGen TOPMed
rs144473418 CA394452357	70	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000957362 CA7856735 rs144473418	70	R>G		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs763334955 CA394452367	70	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7856736 rs763334955	70	R>T		No	ClinGen ExAC TOPMed gnomAD
rs998107980 CA276878707	71	F>C		No	ClinGen TOPMed
CA394452380 rs1205686463	71	F>L		No	ClinGen TOPMed gnomAD
RCV000957363 CA7856739 rs147775375	72	Y>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7856738 rs774782082	72	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA7856740 rs147775375	72	Y>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394452448 rs1287661910	73	D>E		No	ClinGen TOPMed
CA394452440 rs1246043181	73	D>G		No	ClinGen gnomAD
CA7856741 rs753539663	73	D>H		No	ClinGen ExAC gnomAD
CA394452488 rs1567143982	75	M>L		No	ClinGen Ensembl
CA7856742 rs761341688	76	Q>E		No	ClinGen ExAC gnomAD
CA394452571 rs1427947994	78	A>T		No	ClinGen gnomAD
CA394452582 rs1469824970	78	A>V		No	ClinGen gnomAD
rs764907070 CA394452587	79	E>K		No	ClinGen ExAC TOPMed gnomAD
rs764907070 CA7856743	79	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA394452619 rs750210356	80	S>A		No	ClinGen ExAC gnomAD
CA7856744 rs750210356	80	S>P		No	ClinGen ExAC gnomAD
CA394452612 rs750210356	80	S>T		No	ClinGen ExAC gnomAD
rs758158107 CA7856746	81	G>*		No	ClinGen ExAC TOPMed gnomAD
CA7856745 CA394452631 rs758158107	81	G>R		No	ClinGen ExAC TOPMed gnomAD
CA7856748 rs140063808	82	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA394452652 rs140063808	82	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs145687578 COSM1736689 COSM1736688 RCV000881894 CA7856749	82	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs145687578 CA394452662	82	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394452655 rs140063808	82	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs764404714 CA394452687	83	G>*		No	ClinGen ExAC TOPMed gnomAD
CA7856751 rs748418655	83	G>A		No	ClinGen ExAC TOPMed gnomAD
CA7856752 rs748418655	83	G>E		No	ClinGen ExAC TOPMed gnomAD
rs764404714 CA7856750	83	G>R		No	ClinGen ExAC TOPMed gnomAD
rs751803269 CA276878784	84	Q>*		No	ClinGen TOPMed
rs749627881 CA394452728	84	Q>H		No	ClinGen ExAC TOPMed
TCGA novel	85	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs555143181 CA276879672	85	V>A		No	ClinGen 1000Genomes TOPMed gnomAD
rs746827176 CA7856841	85	V>L		No	ClinGen ExAC gnomAD
CA394453355 rs1323479868	86	M>I		No	ClinGen TOPMed gnomAD
CA394453349 rs1281886521	86	M>T		No	ClinGen gnomAD
CA7856842 rs768334620	87	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1222313236 CA394453374	87	S>P		No	ClinGen gnomAD
rs1222313236 CA394453369	87	S>T		No	ClinGen gnomAD
rs748059973 CA7856844	88	S>I		No	ClinGen ExAC TOPMed gnomAD
rs375511525 CA7856845 CA7856846	88	S>R		No	ClinGen ExAC TOPMed gnomAD
rs762969307 CA7856847	89	L>M		No	ClinGen ExAC TOPMed gnomAD
CA394453420 rs1385274355	89	L>R		No	ClinGen TOPMed
rs962695296 CA276879710	90	A>E		No	ClinGen Ensembl
CA7856848 rs766634927	91	E>D		No	ClinGen ExAC gnomAD
CA7856852 rs774367638	92	L>P		No	ClinGen ExAC TOPMed gnomAD
rs774367638 CA394453463	92	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs774367638 CA7856851	92	L>R		No	ClinGen ExAC TOPMed gnomAD
CA7856849 rs1367226412	92	L>V		No	ClinGen TOPMed
CA7856855 rs753306353	93	E>D		No	ClinGen ExAC gnomAD
rs1177236277 CA394453487	93	E>G		No	ClinGen gnomAD
CA394453472 rs140715128	93	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7856853 rs140715128	93	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7856904 rs142297204	95	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394454816 rs142297204	95	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276880195 rs923906431	96	F>L		No	ClinGen TOPMed
rs780479426 CA7856906	97	K>N		No	ClinGen ExAC TOPMed gnomAD
CA7856908 rs747208885	98	E>D		No	ClinGen ExAC TOPMed
CA394454927 rs1173650357	98	E>Q		No	ClinGen gnomAD
rs776886763 CA7856909	99	G>C		No	ClinGen ExAC TOPMed gnomAD
rs762192851 CA7856910	99	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762192851 CA7856911	99	G>V		No	ClinGen ExAC gnomAD
CA7856913 rs151244938	100	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1567146920 CA394455026	100	Y>C		No	ClinGen Ensembl
CA7856912 rs773705481	100	Y>H		No	ClinGen ExAC TOPMed
rs1567146898 CA620419767	100	Y>LL*		No	ClinGen Ensembl
rs767002084 CA394455076	102	E>D		No	ClinGen ExAC gnomAD
rs1319931164 CA394455068	102	E>G		No	ClinGen gnomAD
rs1262666211 CA394455114	103	T>I		No	ClinGen gnomAD
rs1324523222 CA394455142	104	V>G		No	ClinGen TOPMed gnomAD
CA276880275 rs948189979	105	A>E		No	ClinGen gnomAD
CA394455149 rs1240686984	105	A>P		No	ClinGen gnomAD
CA394455147 rs1240686984	105	A>S		No	ClinGen gnomAD
CA394455152 rs1240686984	105	A>T		No	ClinGen gnomAD
COSM1377452 CA394455202 COSM1377451 rs948189979	105	A>V	large_intestine Variant assessed as Somatic; 0.000156 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA394455215 rs1265900523	106	A>T		No	ClinGen gnomAD
CA7856919 rs373258732	107	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1196646153 CA394455253	107	Y>H		No	ClinGen gnomAD
CA7856920 rs757010100	108	Y>D		No	ClinGen ExAC TOPMed gnomAD
rs1177739539 CA394455308	108	Y>S		No	ClinGen gnomAD
CA276880317 rs1046974488	109	E>D		No	ClinGen TOPMed gnomAD
CA7856922 rs750359181	110	E>*		No	ClinGen ExAC TOPMed gnomAD
CA276880339 rs375992790	111	Q>H		No	ClinGen ESP
CA7856923 rs758597913	112	H>N		No	ClinGen ExAC gnomAD
CA7856924 rs141583132 RCV000953026	113	P>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs141583132 CA394455475	113	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1198749662 CA394455791	114	E>Q		No	ClinGen gnomAD
rs766427838 CA7856958	116	T>I		No	ClinGen ExAC gnomAD
CA394455865 rs1291235643	117	P>L		No	ClinGen TOPMed
rs751542510 CA7856959	117	P>S		No	ClinGen ExAC TOPMed gnomAD
rs751542510 CA394455847	117	P>T		No	ClinGen ExAC TOPMed gnomAD
CA394455883 rs755073142	119	L>F		No	ClinGen ExAC TOPMed gnomAD
CA7856961 rs767615947	119	L>P		No	ClinGen ExAC gnomAD
CA7856960 rs755073142	119	L>V		No	ClinGen ExAC TOPMed gnomAD
COSM703185 rs1567149523 CA394455903	120	E>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1466155579 CA394455964	122	E>G		No	ClinGen gnomAD
rs1229385571 CA394455953	122	E>Q		No	ClinGen TOPMed
rs752904266 CA7856963	123	R>K		No	ClinGen ExAC TOPMed gnomAD
CA394456019 rs1452265364	124	D>E		No	ClinGen gnomAD
rs1335253358 CA394456033	125	G>A		No	ClinGen gnomAD
TCGA novel	125	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777924344 CA394456058	127	R>G		No	ClinGen ExAC TOPMed gnomAD
rs754206288 CA394456064	127	R>P		No	ClinGen ExAC TOPMed gnomAD
CA7856966 rs754206288	127	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs777924344 CA7856965	127	R>W		No	ClinGen ExAC TOPMed gnomAD
CA394456089 rs1270072853	128	C>F		No	ClinGen gnomAD
CA394456074 rs1428700109	128	C>S		No	ClinGen TOPMed
CA276881415 rs901230804	128	C>W		No	ClinGen TOPMed gnomAD
CA394456085 rs1270072853	128	C>Y		No	ClinGen gnomAD
CA7856967 rs757614578	129	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1259501964 CA394456108	129	R>Q		No	ClinGen TOPMed gnomAD
CA7856969 COSM281907 rs371449782	130	G>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs779453646 COSM1189154 CA7856968	130	G>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA394456148 rs1225330759	131	N>S		No	ClinGen TOPMed
rs1279030567 CA394456143	131	N>Y		No	ClinGen gnomAD
CA394456157 rs1490017576	132	R>G		No	ClinGen TOPMed
rs1205997554 CA394456176	132	R>S		No	ClinGen TOPMed
rs768089141 CA7856970	133	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7856971 rs768089141	133	S>Y		No	ClinGen ExAC gnomAD
rs1241381099 CA394456196	134	P>A		No	ClinGen gnomAD
CA394456208 rs1478146828	134	P>L		No	ClinGen gnomAD
CA394456211 rs1427350683	135	V>I		No	ClinGen gnomAD
CA7856972 rs567269635	136	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394456243 rs567269635	136	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	136	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762911988 CA7856975	137	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7856976 rs762911988	137	D>N		No	ClinGen ExAC TOPMed gnomAD
CA276881471 rs1031589372	138	V>F		No	ClinGen Ensembl
rs774483172 CA276881481	139	E>D		No	ClinGen ExAC TOPMed gnomAD
CA394456289 rs1399258503	139	E>Q		No	ClinGen gnomAD
CA276881484 rs992493049	140	D>V		No	ClinGen Ensembl
CA394456369 rs1402458039	142	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1343138480 CA394456405	144	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1025895864 CA276881516	145	E>K		No	ClinGen TOPMed gnomAD
CA7856983 rs764366058	147	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1203156122 CA394456480	147	G>R		No	ClinGen gnomAD
CA7856982 rs764366058	147	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1203156122 CA394456486	147	G>W		No	ClinGen gnomAD
CA394456512 rs779217049	148	E>D		No	ClinGen ExAC TOPMed gnomAD
rs757665795 CA276881534	148	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs757665795 CA7856984	148	E>Q		No	ClinGen ExAC gnomAD
rs1266726761 CA394456525	149	S>N		No	ClinGen gnomAD
CA394456578 rs1317124642	151	C>S		No	ClinGen gnomAD
VAR_005506	152	D>N		No	UniProt
rs920380792 CA276881551	154	V>A		No	ClinGen Ensembl
rs750709861 CA7856986	154	V>L		No	ClinGen ExAC gnomAD
rs1379518054 CA394456672	155	M>I		No	ClinGen gnomAD
CA276881553 rs1034287357	155	M>R		No	ClinGen TOPMed
rs758963925 CA7856987	155	M>V		No	ClinGen ExAC gnomAD
rs958331534 CA276881559	157	W>*		No	ClinGen TOPMed
rs1158338689 CA394456707	157	W>R		No	ClinGen gnomAD
rs931479975 CA276881562	158	F>L		No	ClinGen TOPMed
CA7856990 rs570334137	159	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs570334137 CA7856989	159	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394456789 rs1422024423	159	Q>R		No	ClinGen TOPMed gnomAD
CA394456817 rs1204064325	160	A>T		No	ClinGen TOPMed
rs1225116729 CA394456860	161	M>T		No	ClinGen TOPMed
rs748929635 CA7856993	161	M>V		No	ClinGen ExAC gnomAD
rs770892725 CA7856994	163	Q>*		No	ClinGen ExAC gnomAD
rs774320014 CA7856995	164	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA394456958 rs371460714	164	R>W	Variant assessed as Somatic; 4.798e-05 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs759204196 CA7856996	165	L>V		No	ClinGen ExAC gnomAD
rs1289439699 CA394457018	166	Q>*		No	ClinGen gnomAD
rs772061055 CA7856997	166	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1210501469 CA394457064	167	T>N		No	ClinGen gnomAD
CA394457088 rs1269628679	168	W>*		No	ClinGen gnomAD
CA394457089 rs1269628679	168	W>C		No	ClinGen gnomAD
rs775284592 CA7856998	169	W>*		No	ClinGen ExAC gnomAD
CA394457130 rs775284592	169	W>L		No	ClinGen ExAC gnomAD
CA7857002 rs764135077	170	H>Q		No	ClinGen ExAC TOPMed
CA7856999 rs760865971	170	H>Y		No	ClinGen ExAC gnomAD
rs1463194715 CA394457166	171	G>E		No	ClinGen gnomAD
COSM300227 CA7857004 CA7857003 rs538977484	171	G>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD NCI-TCGA
CA394457194 rs1596268306	172	V>G		No	ClinGen Ensembl
rs1458918624 CA394457228	173	L>P		No	ClinGen TOPMed gnomAD
rs374583841 CA7857008	173	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	173	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755737640 CA7857010	174	A>D		No	ClinGen ExAC TOPMed gnomAD
CA7857011 rs755737640	174	A>G		No	ClinGen ExAC TOPMed gnomAD
rs752000903 CA7857009	174	A>P		No	ClinGen ExAC TOPMed gnomAD
CA394457273 rs940293113	175	W>*		No	ClinGen gnomAD
CA394457263 rs1365711104	175	W>R		No	ClinGen gnomAD
rs940293113 CA276881673	175	W>S		No	ClinGen gnomAD
CA7857015 rs756994398	177	K>N		No	ClinGen ExAC gnomAD
rs1239650644 CA394457437	178	E>A		No	ClinGen TOPMed
CA7857017 rs745680533	178	E>D		No	ClinGen ExAC gnomAD
rs778372895 CA7857016	178	E>K		No	ClinGen ExAC gnomAD
CA7857018 rs771750080	179	K>R		No	ClinGen ExAC gnomAD
rs541511099 CA7857019	180	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761820961 CA7857023	181	V>A		No	ClinGen ExAC gnomAD
rs776711769 CA7857022	181	V>M		No	ClinGen ExAC gnomAD
rs765446264 CA7857024	182	A>P		No	ClinGen ExAC TOPMed gnomAD
CA394457511 rs765446264	182	A>S		No	ClinGen ExAC TOPMed gnomAD
CA394457504 rs765446264	182	A>T		No	ClinGen ExAC TOPMed gnomAD
rs773298486 CA7857025	182	A>V		No	ClinGen ExAC gnomAD
CA7857026 rs763437038	183	L>M		No	ClinGen ExAC gnomAD
CA7857027 rs766634535	183	L>P		No	ClinGen ExAC gnomAD
rs763437038 CA394457533	183	L>V		No	ClinGen ExAC gnomAD
CA7857029 rs139497186	184	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394457704 rs753414314	185	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1289837883 CA394457732	186	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs756761335 CA7857032	186	A>T		No	ClinGen ExAC TOPMed gnomAD
CA394457735 rs1289837883	186	A>V		No	ClinGen TOPMed
rs574601205 CA7857033	187	V>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	188	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1567151566 CA394457831	188	Q>R		No	ClinGen Ensembl
TCGA novel	189	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745486455 CA7857034	189	A>V		No	ClinGen ExAC TOPMed gnomAD
rs758251866 CA7857035	195	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs904645833 CA276881832	195	Q>R		No	ClinGen gnomAD
rs779743927 CA7857036	196	S>R		No	ClinGen ExAC
rs1387232574 CA394458184	196	S>T		No	ClinGen TOPMed
CA7857037 rs746754097	197	F>C		No	ClinGen ExAC TOPMed gnomAD
rs768591207 CA394458269	198	C>F		No	ClinGen ExAC gnomAD
rs768591207 CA7857038	198	C>Y		No	ClinGen ExAC gnomAD
CA7857039 rs776480395	199	C>G		No	ClinGen ExAC TOPMed gnomAD
rs776480395 CA7857040	199	C>R		No	ClinGen ExAC TOPMed gnomAD
CA7857041 rs143049351	199	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773536097 CA7857042	200	S>F		No	ClinGen ExAC TOPMed
rs955913137 CA276881898	202	S>*		No	ClinGen Ensembl
CA7857044 rs771147572	202	S>P		No	ClinGen ExAC gnomAD
TCGA novel	204	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7857045 rs368991361	204	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs897865773 CA276881921	205	F>Y		No	ClinGen TOPMed
rs759924800 CA7857046	206	M>I		No	ClinGen ExAC gnomAD
CA7857048 rs768143359	209	F>C		No	ClinGen ExAC TOPMed gnomAD
rs768143359 CA7857047	209	F>S		No	ClinGen ExAC TOPMed gnomAD
CA7857050 rs373154056	210	Q>P		No	ClinGen ESP ExAC gnomAD
rs373154056 CA7857051	210	Q>R		No	ClinGen ESP ExAC gnomAD
rs148189652 CA394458821	212	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7857053 rs779696582	213	G>R		No	ClinGen ExAC TOPMed gnomAD
rs781160848 CA7857056 COSM557735	215	P>T	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs748058182 CA7857060	216	R>G		No	ClinGen ExAC TOPMed
rs531600758 CA7857064	216	R>L		No	ClinGen 1000Genomes ExAC TOPMed
rs531600758 CA7857063	216	R>Q		No	ClinGen 1000Genomes ExAC TOPMed
COSM1189155 CA276881971 rs748058182	216	R>W	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
CA394458988 rs1264224846	217	G>E		No	ClinGen gnomAD
CA7857068 rs749342733	217	G>R		No	ClinGen ExAC TOPMed gnomAD
CA7857075 rs760045825	218	D>E		No	ClinGen ExAC TOPMed gnomAD
CA7857073 rs2981599	218	D>G		No	ClinGen ExAC TOPMed gnomAD
CA394459006 rs141220342 COSM115688	218	D>H	ovary [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA276882039 rs141220342	218	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs141220342 CA7857072	218	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA394459068 rs1596270396	219	K>Q		No	ClinGen Ensembl
CA394459126 rs1253074348	220	E>G		No	ClinGen gnomAD
CA276882061 rs377536439	220	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7857077 rs377536439	220	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7857078 rs150738098	221	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1259393620 CA394459141	221	E>K		No	ClinGen gnomAD
CA7857084 rs766011549	224	P>S		No	ClinGen ExAC TOPMed gnomAD
rs751197524 CA7857085	225	Q>*		No	ClinGen ExAC gnomAD
CA394459327 rs140102091	225	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1177939943 CA394459374	227	C>G		No	ClinGen gnomAD
rs780936859 CA7857087	227	C>Y		No	ClinGen ExAC gnomAD
rs143941291 CA7857089	230	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7857090 rs143941291	230	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7857092 rs147297738	231	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1371111124 CA394459512	231	Q>R		No	ClinGen TOPMed
CA394459538 rs746055082	232	S>C		No	ClinGen ExAC gnomAD
rs746055082 CA7857094	232	S>F		No	ClinGen ExAC gnomAD
rs369007437 CA7857096	233	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs369007437 CA7857097	233	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs769043924 CA7857099	234	K>E		No	ClinGen ExAC gnomAD
rs769043924 CA7857098	234	K>Q		No	ClinGen ExAC gnomAD

No associated diseases with P24001

1 regional properties for P24001

Type	Name	Position	InterPro Accession
domain	CBM21 (carbohydrate binding type-21) domain	150 - 258	IPR005036

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name	Definition
cytokine activity	The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.

7 GO annotations of biological process

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
defense response	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
negative regulation of viral life cycle	Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
positive regulation of type III interferon production	Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MCFPKVLSDD	MKKLKARMVM	LLPTSAQGLG	AWVSACDTED	TVGHLGPWRD	KDPALWCQLC
70	80	90	100	110	120
LSSQHQAIER	FYDKMQNAES	GRGQVMSSLA	ELEDDFKEGY	LETVAAYYEE	QHPELTPLLE
130	140	150	160	170	180
KERDGLRCRG	NRSPVPDVED	PATEEPGESF	CDKVMRWFQA	MLQRLQTWWH	GVLAWVKEKV
190	200	210	220	230
VALVHAVQAL	WKQFQSFCCS	LSELFMSSFQ	SYGAPRGDKE	ELTPQKCSEP	QSSK