AiPD: Autoinhibited Protein Database

Gene name	cydC (mdrA, mdrH, surB, b0886, JW0869)
Protein name	ATP-binding/permease protein CydC
Names
Species	Escherichia coli (strain K12)
KEGG Pathway	eco:b0886
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

291-361 (Predicted disordered autoinhibitory region) PR

291-361 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
7ZD5	EM	317 A	C	1-573	PDB
7ZDA	EM	317 A	C	1-573	PDB
7ZDB	EM	335 A	C	1-573	PDB
7ZDC	EM	313 A	C	1-573	PDB
7ZDE	EM	317 A	C	1-573	PDB
7ZDF	EM	294 A	C	1-573	PDB
7ZDG	EM	277 A	C	1-573	PDB
7ZDK	EM	301 A	C	1-573	PDB
7ZDL	EM	335 A	C	1-573	PDB
7ZDR	EM	305 A	C	1-573	PDB
7ZDS	EM	326 A	C	1-573	PDB
7ZDT	EM	271 A	C	1-573	PDB
7ZDU	EM	298 A	C	1-573	PDB
7ZDV	EM	305 A	C	1-573	PDB
7ZDW	EM	335 A	C	1-573	PDB
7ZE5	EM	294 A	C	1-573	PDB
7ZEC	EM	305 A	C	1-573	PDB
8IPS	EM	360 A	A	1-573	PDB
8IPT	EM	350 A	C/D	1-573	PDB
AF-P23886-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P23886

Type	Name	Position	InterPro Accession
domain	ABC transporter-like, ATP-binding domain	339 - 572	IPR003439
domain	AAA+ ATPase domain	365 - 549	IPR003593
domain	ABC transporter type 1, transmembrane domain	20 - 306	IPR011527
conserved_site	ABC transporter-like, conserved site	475 - 489	IPR017871

		Description
EC Number
Subcellular Localization	Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
ATP-binding cassette (ABC) transporter complex	A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
ABC-type transporter activity	Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled transmembrane transporter activity	Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

Name	Definition
cell redox homeostasis	Any process that maintains the redox environment of a cell or compartment within a cell.
cysteine export across plasma membrane	The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region.
glutathione transmembrane transport	A process in which glutathione is transported across a membrane.
regulation of heme biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins