P23872

PR
Gene name
aes (ybaC, b0476, JW0465)
Protein name
Acetyl esterase
Names
EcE
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0476
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P23872

Entry ID Method Resolution Chain Position Source
4KRX X-ray 180 A A/B/C 1-319 PDB
4KRY X-ray 230 A A/B/C/D/E/F 1-319 PDB
AF-P23872-F1 Predicted AlphaFoldDB

No variants for P23872

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P23872

No associated diseases with P23872

3 regional properties for P23872

Type Name Position InterPro Accession
active_site Lipase, GDXG, putative histidine active site 87 - 103 IPR002168
domain Alpha/beta hydrolase fold-3 87 - 295 IPR013094
active_site Lipase, GDXG, putative serine active site 159 - 171 IPR033140

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
acetylesterase activity Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
short-chain carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.

2 GO annotations of biological process

Name Definition
negative regulation of DNA-binding transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
negative regulation of hydrolase activity Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKPENKLPVL DLISAEMKTV VNTLQPDLPP WPATGTIAEQ RQYYTLERRF WNAGAPEMAT
70 80 90 100 110 120
RAYMVPTKYG QVETRLFCPQ PDSPATLFYL HGGGFILGNL DTHDRIMRLL ASYSQCTVIG
130 140 150 160 170 180
IDYTLSPEAR FPQAIEEIVA ACCYFHQQAE DYQINMSRIG FAGDSAGAML ALASALWLRD
190 200 210 220 230 240
KQIDCGKVAG VLLWYGLYGL RDSVTRRLLG GVWDGLTQQD LQMYEEAYLS NDADRESPYY
250 260 270 280 290 300
CLFNNDLTRE VPPCFIAGAE FDPLLDDSRL LYQTLAAHQQ PCEFKLYPGT LHAFLHYSRM
310
MKTADEALRD GAQFFTAQL