P23621

PR
Gene name
phoR (PA5361)
Protein name
Phosphate regulon sensor protein PhoR
Names
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA5361
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

60-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P23621

Entry ID Method Resolution Chain Position Source
AF-P23621-F1 Predicted AlphaFoldDB

No variants for P23621

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P23621

No associated diseases with P23621

9 regional properties for P23621

Type Name Position InterPro Accession
domain PAS domain 93 - 219 IPR000014
domain Histidine kinase/HSP90-like ATPase 321 - 433 IPR003594
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 207 - 276 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 358 - 372 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 376 - 386 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 393 - 411 IPR004358-3
domain Signal transduction histidine kinase-related protein, C-terminal 417 - 430 IPR004358-4
domain Histidine kinase domain 216 - 433 IPR005467
domain PAS fold 102 - 156 IPR013767

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

3 GO annotations of biological process

Name Definition
cellular response to phosphate starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
phosphate ion transport The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQSVVNQDWR GALIRHLLLV LAASLVLGVV SGHYGWALAL GLALYLGWTL WQLLRLHQWL
70 80 90 100 110 120
RNHQPDEPPP DSYGLWGEVF DNIYHLQRRN QRARGRLQAV IDRIQESTAA LRDAVIMLDS
130 140 150 160 170 180
DGNLEWWNLA AENLLGLKTP QDGGQPVSNL IRHPRFKEYF DQEDYREPLE IPSPINERLR
190 200 210 220 230 240
LQFHITLYGN REHLMLVRDV TRVHQLEQMR KDFVANVSHE LRTPLTVIAG YLETLLDNVE
250 260 270 280 290 300
DVNPRWLRAL QQMQQQAGRM QNLLNDLLLL AKLEATDYPG DNKPVAVDAL LASIRNDAQA
310 320 330 340 350 360
LSAGRNHRIS LDAAPAVQLK GSEAELRSAF SNLVFNAVKY TPDEGEIRIR WWADEQGAHL
370 380 390 400 410 420
SVQDTGIGVD PKHLPRLTER FYRVDSSRAS NTGGTGLGLA IVKHVLIRHR ARLEISSVPG
430 440
KGSTFTCHFA PAQVAEAERK APK