P23612

PR
Gene name
WARS1 (WARS)
Protein name
Tryptophan--tRNA ligase, cytoplasmic
Names
Tryptophanyl-tRNA synthetase, TrpRS
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009123
EC number
6.1.1.2: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P23612

Entry ID Method Resolution Chain Position Source
AF-P23612-F1 Predicted AlphaFoldDB

No variants for P23612

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P23612

No associated diseases with P23612

2 regional properties for P23612

Type Name Position InterPro Accession
domain WHEP-TRS domain 12 - 74 IPR000738
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 168 - 178 IPR001412

Functions

Description
EC Number 6.1.1.2 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tryptophan-tRNA ligase activity Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).

2 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADVTNGERC ASPQELFSSI AAQGELVKSL KARKAPKEEI DSAVKMLLSL KTSYKEAMGE
70 80 90 100 110 120
DYKADCPPGN STPDSHGDPE AVDDKEDFVD PWTVRTSSAK GIDYDKLIVQ FGSSKIDKEL
130 140 150 160 170 180
VNRIERATGQ RPHRFLRRGI FFSHRDMNQV LDAYENKKPF YLYTGRGPSS EAMHVGHLIP
190 200 210 220 230 240
FIFTKWLQDV FDVPLVVQMS DDEKYLWKDL TLEQVYGYTL ENAKDIIACG FDVNKTFIFS
250 260 270 280 290 300
DLDYMGMSPG FYKNVVKIQK HVTFNQVKGI FGFTDSDCIG KISFPAIQAA PSFSNSFPQI
310 320 330 340 350 360
FHGQADIQCL IPCAIDQDPY FRMTRDVAPR IGYPKPALLH STFFPALQGA QTKMSASDPN
370 380 390 400 410 420
SSIFLTDTAK QIKTKVNKHA FSGGRDTIEE HRQFGGNCDV DVSFMYLTFF LEDDDKLEQI
430 440 450 460 470
RKDYSSGAML TGELKKELID VLQPLVAEHQ ARRKEVTDEM VKEFMTPRQL CFHYQ