P22868

PR
Gene name
mmoC (MCA1200)
Protein name
Methane monooxygenase component C
Names
Methane hydroxylase, Methane monooxygenase reductase, MMOR
Species
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
KEGG Pathway
mca:MCA1200
EC number
1.14.13.25: With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

260-331 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P22868

Entry ID Method Resolution Chain Position Source
1JQ4 NMR - A 1-98 PDB
1TVC NMR - A 99-348 PDB
AF-P22868-F1 Predicted AlphaFoldDB

No variants for P22868

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P22868

No associated diseases with P22868

9 regional properties for P22868

Type Name Position InterPro Accession
domain 2Fe-2S ferredoxin-type iron-sulfur binding domain 5 - 98 IPR001041
domain Oxidoreductase FAD/NAD(P)-binding 220 - 324 IPR001433
domain Flavoprotein pyridine nucleotide cytochrome reductase 159 - 166 IPR001709-1
domain Flavoprotein pyridine nucleotide cytochrome reductase 219 - 238 IPR001709-2
domain Flavoprotein pyridine nucleotide cytochrome reductase 244 - 253 IPR001709-3
domain Flavoprotein pyridine nucleotide cytochrome reductase 310 - 318 IPR001709-4
binding_site 2Fe-2S ferredoxin, iron-sulphur binding site 42 - 50 IPR006058
domain Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain 115 - 208 IPR008333
domain FAD-binding domain, ferredoxin reductase-type 106 - 211 IPR017927

Functions

Description
EC Number 1.14.13.25 With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
metal ion binding Binding to a metal ion.
methane monooxygenase NADH activity Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O.
methane monooxygenase NADPH activity Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O.

1 GO annotations of biological process

Name Definition
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRVHTITAV TEDGESLRFE CRSDEDVITA ALRQNIFLMS SCREGGCATC KALCSEGDYD
70 80 90 100 110 120
LKGCSVQALP PEEEEEGLVL LCRTYPKTDL EIELPYTHCR ISFGEVGSFE AEVVGLNWVS
130 140 150 160 170 180
SNTVQFLLQK RPDECGNRGV KFEPGQFMDL TIPGTDVSRS YSPANLPNPE GRLEFLIRVL
190 200 210 220 230 240
PEGRFSDYLR NDARVGQVLS VKGPLGVFGL KERGMAPRYF VAGGTGLAPV VSMVRQMQEW
250 260 270 280 290 300
TAPNETRIYF GVNTEPELFY IDELKSLERS MRNLTVKACV WHPSGDWEGE QGSPIDALRE
310 320 330 340
DLESSDANPD IYLCGPPGMI DAACELVRSR GIPGEQVFFE KFLPSGAA