P22823
Gene name |
pdh |
Protein name |
Phenylalanine dehydrogenase |
Names |
PheDH |
Species |
Thermoactinomyces intermedius |
KEGG Pathway |
|
EC number |
1.4.1.20: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P22823
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P22823-F1 | Predicted | AlphaFoldDB |
No variants for P22823
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P22823 | |||||
No associated diseases with P22823
3 regional properties for P22823
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal | 148 - 354 | IPR006096 |
| domain | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain | 13 - 130 | IPR006097 |
| active_site | Leu/Phe/Val dehydrogenases active site | 75 - 88 | IPR033524 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.1.20 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phenylalanine dehydrogenase activity | Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| L-phenylalanine biosynthetic process | The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRDVFEMMDR | YGHEQVIFCR | HPQTGLKAII | ALHNTTAGPA | LGGCRMIPYA | STDEALEDVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLSKGMTYKC | SLADVDFGGG | KMVIIGDPKK | DKSPELFRVI | GRFVGGLNGR | FYTGTDMGTN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEDFVHAARE | SKSFAGLPKS | YGGKGDTSIP | TALGVFHGMR | ATARFLWGTD | QLKGRVVAIQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVGKVGERLL | QLLVEVGAYC | KIADIDSVRC | EQLKEKYGDK | VQLVDVNRIH | KESCDIFSPC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AKGGVVNDDT | IDEFRCLAIV | GSANNQLVED | RHGALLQKRS | ICYAPDYLVN | AGGLIQVADE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEGFHEERVL | AKTEAIYDMV | LDIFHRAKNE | NITTCEAADR | IVMERLKKLT | DIRRILLEDP |
| RNSARR |